ArticleCerebral cortex (New York, N.Y. : 1991)2020
Subthalamic Nucleus Activity Influences Sensory and Motor Cortex during Force Transduction.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Subthalamic nucleus in patients with Parkinson's disease encodes changes and magnitude of applied force.NPJ Parkinson's disease · 2026Article
- Spike-phase coupling of subthalamic neurons to posterior perisylvian cortex predicts speech sound accuracy.Nature communications · 2025Article
- Stage-dependent role of interhemispheric pathway for motor recovery in primates.Nature communications · 2024Article
- Subthalamic stimulation modulates context-dependent effects of beta bursts during fine motor control.Nature communications · 2024Article
- Contribution of the subthalamic nucleus to motor, cognitive and limbic processes: an electrophysiological and stimulation study in monkeys.Frontiers in neuroscience · 2024Article
- Dynamic modulation of subthalamic nucleus activity facilitates adaptive behavior.PLoS biology · 2023Article
- Lexicality-Modulated Influence of Auditory Cortex on Subthalamic Nucleus During Motor Planning for Speech.Neurobiology of language (Cambridge, Mass.) · 2023Article
- Deep brain stimulation for parkinson's disease induces spontaneous cortical hypersynchrony in extended motor and cognitive networks.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Article
- Articulatory Gain Predicts Motor Cortex and Subthalamic Nucleus Activity During Speech.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Article
- The Control of Movements via Motor Gamma Oscillations.Frontiers in human neuroscience · 2021Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The subthalamic nucleus (STN) is proposed to participate in pausing, or alternately, in dynamic scaling of behavioral responses, roles that have conflicting implications for understanding STN function in the context of deep brain stimulation (DBS) therapy. To examine the nature of event-related STN activity and subthalamic-cortical dynamics, we performed primary motor and somatosensory electrocorticography while subjects (n = 10) performed a grip force task during DBS implantation surgery. Phase-locking analyses demonstrated periods of STN-cortical coherence that bracketed force transduction, in both beta and gamma ranges. Event-related causality measures demonstrated that both STN beta and gamma activity predicted motor cortical beta and gamma activity not only during force generation but also prior to movement onset. These findings are consistent with the idea that the STN participates in motor planning, in addition to the modulation of ongoing movement. We also demonstrated bidirectional information flow between the STN and somatosensory cortex in both beta and gamma range frequencies, suggesting robust STN participation in somatosensory integration. In fact, interactions in beta activity between the STN and somatosensory cortex, and not between STN and motor cortex, predicted PD symptom severity. Thus, the STN contributes to multiple aspects of sensorimotor behavior dynamically across time.
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