ArticleResearch and practice in thrombosis and haemostasis2020
Clinical variables that increase the probability of pulmonary embolism diagnosis in symptomatic children.
Article in Research and practice in thrombosis and haemostasis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Pulmonary embolism complicatingFrontiers in pediatrics · 2025Article
- Pulmonary embolism in pediatrics: A 10-year experience from a tertiary center in Brazil.Hematology, transfusion and cell therapy · 2023Article
- Bedside exclusion of pulmonary embolism in children without radiation (BEEPER): a national study of the Pediatric Emergency Care Applied Research Network-Study protocol.Research and practice in thrombosis and haemostasis · 2023Article
- COVID-19 Infection and Acute Pulmonary Embolism in an Adolescent Female With Sickle Cell Disease.Cureus · 2020Article
- Clinical variables that increase the probability of pulmonary embolism diagnosis in symptomatic children.Research and practice in thrombosis and haemostasis · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPulmonary embolism (PE) in children carries a significant morbidity and mortality. We examined previously described factors in 2 cohorts of children tested for PE and identified novel factors.
methodsWe combined data from 2 retrospective cohorts. Patients up to age 21 years were included who underwent imaging or D-dimer testing for PE, with positive radiologic testing being the gold standard. Combined predictor variables were examined by univariate analysis and then forward stepwise multivariable logistic regression.
resultsThe combined data set yielded 1103 patients with 42 unique predictor variables, and 93 PE-positive patients (8.4%), with a median age of 16 years. Univariate analysis retained 17 variables, and multivariable logistic regression found 9 significant variables with increased probability of PE diagnosis: age-adjusted tachycardia, tachypnea, hypoxia, unilateral limb swelling, trauma/surgery requiring hospitalization in previous 4 weeks, prior thromboembolism, cancer, anemia, and leukocytosis.
conclusionThis combined data set of children with suspected PE discovered factors that may contribute to a diagnosis of PE: hypoxia, unilateral limb swelling, trauma/surgery requiring hospitalization in previous 4 weeks, prior thromboembolism, and cancer, age-adjusted tachycardia, tachypnea, anemia, and leukocytosis. Prospective testing is needed to determine which criteria should be used to initiate diagnostic testing for PE in children.
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Registered trials
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