Evidence map›Paper›PMID 31989039›Full record

ArticleBioengineering & translational medicine2020

CRISPR/Cas9-mediated mutagenesis to validate the synergy between PARP1 inhibition and chemotherapy in

Rachel L Mintz, Yeh-Hsing Lao, Chun-Wei Chi, Siyu He, Mingqiang Li, Chai Hoon Quek, Dan Shao, Boyuan Chen, Jing Han, Sihong Wang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering & translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
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  3. Multidrug Resistance: Are We Still Afraid of the Big Bad Wolf.Pharmaceuticals (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Rachel L MintzDepartment of Biomedical Engineering Columbia University New York New York.
Yeh-Hsing LaoDepartment of Biomedical Engineering Columbia University New York New York.
Chun-Wei ChiDepartment of Biomedical Engineering CUNY-City College of New York New York New York.
Siyu HeDepartment of Biomedical Engineering Columbia University New York New York.
Mingqiang LiDepartment of Biomedical Engineering Columbia University New York New York.
Chai Hoon QuekDepartment of Biomedical Engineering Columbia University New York New York.
Dan ShaoDepartment of Biomedical Engineering Columbia University New York New York.
Boyuan ChenDepartment of Biomedical Engineering Columbia University New York New York.
Jing HanDepartment of Biomedical Engineering Columbia University New York New York.
Sihong WangDepartment of Biomedical Engineering CUNY-City College of New York New York New York.
Kam W LeongDepartment of Biomedical Engineering Columbia University New York New York.ORCID https://orcid.org/0000-0002-8133-4955
Columbia University · USCity College of New York · USChinese Academy of Sciences · CNColumbia University Irving Medical Center · USSun Yat-sen University · CN

Funding

Integrated Microphysiological System of Cerebral Organoid and Blood Vessel for Disease Modeling and Neuropsychiatric Drug screeningUG3TR002151 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEONG, KAM W · 2018 to 2019
$2.6M
BD Biosciences InfluxS10OD020056 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2015 to 2015
$600k
NCATS NIH HHS UG3 TR002151NIH HHS S10 OD020056
6 · The paper itself

Abstract

For patients carrying

Indexed as

BRCA1CRISPR/Cas9PARP1precision medicinesynthetic lethalitytriple negative breast cancer

Identifiers

PMID31989039
PMCPMC6971465
OpenAlexW2994984819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.