Evidence map›Paper›PMID 31988992›Full record

ArticleRegenerative therapy2020

Implantation of allogenic umbilical cord blood-derived mesenchymal stem cells improves knee osteoarthritis outcomes: Two-year follow-up.

Jun-Seob Song, Ki-Taek Hong, Na-Min Kim, Jae-Yub Jung, Han-Soo Park, Sang Heon Lee, Yoon Joo Cho, Seok Jung Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 5 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 5 syntheses or guidelines pooled it, 59 citations in OpenAlex.

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  10. Observational
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  18. Efficacy and safety of mesenchymal stem cell injections for knee osteoarthritis: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jun-Seob SongDepartment of Orthopaedic Surgery, Gangnam JS Hospital, Seoul, Republic of Korea.
Ki-Taek HongDepartment of Orthopaedic Surgery, Gangnam JS Hospital, Seoul, Republic of Korea.
Na-Min KimDepartment of Orthopaedic Surgery, Gangnam JS Hospital, Seoul, Republic of Korea.
Jae-Yub JungDepartment of Orthopaedic Surgery, Gangnam JS Hospital, Seoul, Republic of Korea.
Han-Soo ParkDepartment of Orthopaedic Surgery, Gangnam JS Hospital, Seoul, Republic of Korea.
Sang Heon LeeDepartment of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Yoon Joo ChoDepartment of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Seok Jung KimDepartment of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Catholic University of Korea · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionClinical outcomes after the implantation of allogenic human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in osteoarthritic knees have been rarely reported. Our study aimed to investigate clinical outcomes of osteoarthritic patients who underwent hUCB-MSC implantation.

methodsIn this case series (level of evidence: 4), from January 2014 to December 2015, 128 patients with full-thickness cartilage lesions (International Cartilage Repair Society grade 4 and Kellgren-Lawrence grade ≤3) who underwent hUCB-MSC implantation were retrospectively evaluated with a minimum of 2-year follow-up. After removing the sclerotic subchondral bone with an arthroscopic burr, 4-mm-diameter holes were created at 2-mm intervals, and hyaluronic acid and hUCB-MSCs were subsequently mixed and implanted in the holes and other articular defect sites.Clinical outcomes were evaluated preoperatively, 1 year postoperatively, and 2 years postoperatively (minimum) using visual analog scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and International Knee Documentation Committee (IKDC) scores. To assess clinical outcomes, patients were divided into two or three groups according to the lesion size, lesion location, number of lesions, body mass index, and age; statistical analyses were performed using these data.

resultsThe mean (±standard deviation) VAS, WOMAC, and IKDC scores at 1 and 2 years after surgery including hUCB-MSC implantation improved significantly compared to the preoperative scores (

conclusionsImplantation of hUCB-MSCs is effective for treating knee osteoarthritis based on a follow-up lasting a minimum of 2 years.

Indexed as

ACI, autologous chondrocyte implantationAllogenicAT-MSCs, adipose tissue-derived MSCsBMI, body mass indexBM-MSCs, bone marrow-derived MSCsHA, hyaluronic acidhUCB-MSCs, human umbilical cord blood-derived mesenchymal stem cellsHuman umbilical cord bloodIKDC, International Knee Documentation CommitteeKL, Kellgren–LawrenceKnee osteoarthritisLFC, lateral femoral condyleMesenchymal stem cellsMFC, medial femoral condyleMRI, magnetic resonance imagingOA, osteoarthritisOAT, osteochondral autologous transplantationVAS, visual analog scaleWOMAC, Western Ontario and McMaster Universities Osteoarthritis Index

Identifiers

PMID31988992
PMCPMC6965506
OpenAlexW2999433340

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.