Evidence map›Paper›PMID 31988919›Full record

ArticleBiomedicine hub

Total Outflow Facility in Live C57BL/6 Mice of Different Age.

Aleksandr Yelenskiy, MinHee K Ko, Edward R Chu, Jose M Gonzalez, Kimberly Siegmund, James C Tan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicine hub. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Aleksandr YelenskiyDoheny Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA, USA.
MinHee K KoDoheny Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA, USA.
Edward R ChuDoheny Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA, USA.
Jose M GonzalezDoheny Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA, USA.
Kimberly SiegmundDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
James C TanDoheny Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · USTulane University · USUniversity of Southern California · US

Funding

VISION RESEARCHP30EY003040 · NEI · DOHENY EYE INSTITUTE · PI SUN, DEMING · 1985 to 2013
$7.0M
Role of trabecular meshwork contractility in modulating outflow resistanceK08EY020863 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TAN, CHEE HIAN · 2010 to 2013
$981k
NEI NIH HHS K08 EY020863NEI NIH HHS P30 EY003040
6 · The paper itself

Abstract

purposeTo characterize total outflow facility across the live adult mouse lifespan as a reference for mouse glaucoma studies and the common C57BL/6 background strain.

methodsMicroperfusion was performed by single-needle cannulation and feedback-controlled coupling of pressure and flow to maintain a constant pressure in the anterior chambers of live C57BL/6NCrl mice aged 3-4 months (

resultsPressure-flow rate functions were consistently linear for all age groups (all

conclusionWe did not find a significant difference in total outflow facility between different age groups across the live C57BL/6 mouse adult lifespan, agreeing with some human studies. The possibility that more subtle differences might exist ought to be judged with respect to the heterogeneity in facility at different ages. Our findings provide reference data for live perfusion studies pertaining to glaucoma involving the C57BL/6 strain.

Indexed as

C57BL/6GlaucomaOutflow facilityPerfusion apparatusTrabecular meshwork

Identifiers

PMID31988919
PMCPMC6945946
OpenAlexW2770674402

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.