Evidence map›Paper›PMID 31988912›Full record

ArticleBiomedicine hub

The Dipeptidyl Peptidase-4 Inhibitor Teneligliptin Reduces Aortic Damage from Hypercholesterolaemia in Apolipoprotein E-Deficient Mice.

Ying Zhang, Nan Wang, Liyue Zhu, Yingshu Liu, Zuowei Pei, Guan Wang, Lin Luo, Hongyang Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicine hub. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Ying ZhangDepartment of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Nan WangDepartment of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Liyue ZhuRehabilitation Center, Zhejiang Hospital, Hangzhou, China.
Yingshu LiuDepartment of Endocrinology, Dalian Municipal Central Hospital, Dalian, China.
Zuowei PeiDepartment of Cardiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Guan WangInternational Medical Department, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Lin LuoDepartment of Central Intensive Care Unit (ICU), The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Hongyang LiuDepartment of Heart Intensive Care Unit, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Dalian Medical University · CNAffiliated Zhongshan Hospital of Dalian University · CNDalian Municipal Central Hospital · CNZhejiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHypercholesterolaemia is a well-established risk factor for blood vessel damage, which can lead to cardiovascular diseases. An abundance of clinical data show that dipeptidyl peptidase-4 inhibitors protect against aortic damage in patients with diabetes. The goal of this study was to investigate the possible protective effects of teneligliptin against aortic damage in apolipoprotein E knockout (ApoE

methodsEight-week-old male ApoE RESULTS AND

conclusionThe metabolic characteristics of total cholesterol, low-density lipoprotein-cholesterol, and high-sensitivity C-reactive protein were lower in ApoE

Indexed as

Aortic damageApoE−/– miceDipeptidyl peptidase-4Hypercholesterolaemia

Identifiers

PMID31988912
PMCPMC6945959
OpenAlexW2614198834

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.