ArticleBiomedicine hub
Long-Term Ultraviolet A Eye Irradiation Causes Retina Denaturation in Mice.
Article in Biomedicine hub. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- Aging in Ocular Blood Vessels: Molecular Insights and the Role of Oxidative Stress.Biomedicines · 2024Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong-term ultraviolet (UV) A eye irradiation in mice initiates the induction of photoaging. However, the changes in the eye due to long-term exposure to UVA radiation are still unclear.
methodsMale C57BL/6j (control) and inducible nitric oxide synthase knockout (iNOS
resultsThe expression of iNOS, matrix metalloproteinase-2 (MMP-2), MMP-9, vascular endothelial growth factor, β-amyloid, and macrophages in the retina all increased after UVA irradiation. Furthermore, in the iNOS
conclusionsThese results indicated that long-term UVA eye irradiation led to iNOS-induced denaturation of the retina; however, further studies are needed to confirm these findings.
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Registered trials
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