ArticleJournal of maxillofacial and oral surgery2020
Incidence of Micrometastasis and Isolated Tumour Cells in Clinicopathologically Node-Negative Head and Neck Squamous Cell Carcinoma.
Article in Journal of maxillofacial and oral surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Review
- Automated Lymph Node Localization and Segmentation in Patients with Head and Neck Cancer: Opportunities and Limitations of Using a Generic AI Model.Diagnostics (Basel, Switzerland) · 2026Article
- Assessment of occult cervical metastases in oral cavity squamous cell carcinoma: Findings from a tertiary-level hospital study.Journal of clinical and experimental dentistry · 2025Review
- Development and validation of deep learning models for qualitative classification of benign and malignant enlarged cervical lymph nodes based on ultrasound images.Gland surgery · 2025Article
- Do patients with cN0 oral squamous cell carcinoma benefit from elective neck dissection? A large-scale population-based study.BMC oral health · 2024Article
- Quantification of oxygen consumption in head and neck cancer using fluorescent sensor foil technology.Frontiers in oncology · 2024Article
- Level V Metastases in Node-Positive Oral Squamous Cell Carcinoma: Beyond Level IIA and III.ORL; journal for oto-rhino-laryngology and its related specialties · 2024Article
- Comparing the Diagnostic Accuracy of Ultrasonography, CT, MRI, and PET/CT in Cervical Lymph Node Metastasis of Oral Squamous Cell Carcinoma.Biomedicines · 2023Article
- Critical Review of the Current Evidence on Sentinel Node Biopsy in Oral Cancer.Current oncology reports · 2022Review
- Sentinel node biopsy or elective neck dissection in early oral cancer: a point of contention.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma.Scientific reports · 2021Article
- Micro-metastasis and isolated tumour cells: the span between elective neck dissection versus neck observation in early oral cancer.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020Article
- In reply to the letter to the editor regarding "Micro-metastasis and Isolated tumour cells: The span between Elective Neck Dissection versus Neck Observation in Early oral cancer".European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020Article
- Tumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology report.PloS one · 2020Article
- Level IIb Metastases in cN0 Oral Squamous Cell Carcinoma: Multicenter Retrospective Study.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialeArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOccult neck node metastasis in head and neck squamous cell carcinoma (HNSCC) in the form of micrometastasis and isolated tumour cell (ITC) often goes unnoticed in the routine pathological examination. This limitation can be overcome by using serial sectioning and immunohistochemistry for detection of micrometastasis and ITC in clinically and pathologically node-negative neck. The primary objective was to determine the incidence of micrometastasis and ITC in the selective neck dissection specimen, whereas to determine the levels of lymph nodes involved, depending upon the site of primary tumour, was the secondary objective. MATERIALS AND
methodsLymph nodes from selective neck dissection specimen were subjected to serial sectioning and immunohistochemistry with pan-cytokeratin marker. Incidence of micrometastasis and ITC, site and stage of primary tumours and level of lymph nodes involved were determined.
resultsIn total, 8.8% patients in the study got upstaged after serial sectioning and immunohistochemistry. Tongue and lower alveolar primaries showed the presence of micrometastasis and ITC in neck nodes. All the primary tumours were of pT1 stage. Level IB and II lymph nodes were primarily involved.
conclusionMicrometastasis and isolated tumour cells are found in approximately 9% of cases of early-stage oral cavity squamous cell carcinoma. The predictive factors and clinical significance are still unknown. More prospective trials are required to solve this evolving aspect of HNSCC.
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