Evidence map›Paper›PMID 31988513›Full record

ArticleNature materials2020

Rapid fabrication of precise high-throughput filters from membrane protein nanosheets.

Yu-Ming Tu, Woochul Song, Tingwei Ren, Yue-Xiao Shen, Ratul Chowdhury, Prasangi Rajapaksha, Tyler E Culp, Laxmicharan Samineni, Chao Lang, Alina Thokkadam and 14 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Generative design of programmable asymmetric β-barrel nanopores.bioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Bottom-up synthesis of graphene films hosting atom-thick molecular-sieving apertures.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  10. De novo design of transmembrane β barrels.Science (New York, N.Y.) · 2021
    Article
  11. Patterning MOFs at smaller scales.Nature materials · 2021
    Article
  12. Article
  13. Review
  14. Proteins tailor pore geometry.Nature materials · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Yu-Ming Tu *Department of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
Woochul Song *Department of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
Tingwei Ren *Department of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
Yue-Xiao ShenDepartment of Civil, Environmental, & Construction Engineering, Texas Tech University, Lubbock, TX, USA.
Ratul ChowdhuryDepartment of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0000-0003-4522-6911
Prasangi RajapakshaDepartment of Chemistry, University of Kentucky, Lexington, KY, USA.
Tyler E CulpDepartment of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
Laxmicharan SamineniDepartment of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
Chao LangDepartment of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
Alina ThokkadamDepartment of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ, USA.
Drew CarsonDepartment of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
Yuxuan DaiDepartment of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
Arwa MuktharDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.
Miaoci ZhangDepartment of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
Andrey ParshinApplied Biomimetic, Gaithersburg, MD, USA.
Janna N SloandDepartment of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA.
Scott H MedinaDepartment of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA.
Mariusz GrzelakowskiApplied Biomimetic, Gaithersburg, MD, USA.
Dibakar BhattacharyaDepartment of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA.
William A PhillipDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN, USA.
Enrique D GomezDepartment of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
Robert J HickeyDepartment of Materials Science and Engineering, The Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0000-0001-6808-7411
Yinai WeiDepartment of Chemistry, University of Kentucky, Lexington, KY, USA.
Manish KumarDepartment of Chemical Engineering, Pennsylvania State University, University Park, PA, USA. manish.kumar@utexas.edu.ORCID http://orcid.org/0000-0001-5545-3793

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biological membranes are ideal for separations as they provide high permeability while maintaining high solute selectivity due to the presence of specialized membrane protein (MP) channels. However, successful integration of MPs into manufactured membranes has remained a significant challenge. Here, we demonstrate a two-hour organic solvent method to develop 2D crystals and nanosheets of highly packed pore-forming MPs in block copolymers (BCPs). We then integrate these hybrid materials into scalable MP-BCP biomimetic membranes. These MP-BCP nanosheet membranes maintain the molecular selectivity of the three types of β-barrel MP channels used, with pore sizes of 0.8 nm, 1.3 nm, and 1.5 nm. These biomimetic membranes demonstrate water permeability that is 20-1,000 times greater than that of commercial membranes and 1.5-45 times greater than that of the latest research membranes with comparable molecular exclusion ratings. This approach could provide high performance alternatives in the challenging sub-nanometre to few-nanometre size range.

Indexed as

Membranes, ArtificialMembrane ProteinsModels, MolecularNanostructuresPermeabilityPorosityProtein Conformation, beta-StrandSolventsTime FactorsMembrane ProteinsMembranes, ArtificialSolvents

Identifiers

PMID31988513

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.