Evidence map›Paper›PMID 31988488›Full record

ArticleThe pharmacogenomics journal2020

Prognostic role of SCAMP family in acute myeloid leukemia.

Tingting Qian, Zhiheng Cheng, Liang Quan, Tiansheng Zeng, Longzhen Cui, Yan Liu, Chaozeng Si, Wenhui Huang, Yifeng Dai, Jinghong Chen and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in The pharmacogenomics journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Tingting Qian *Department of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, 510260, Guangzhou, China.
Zhiheng Cheng *Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.ORCID http://orcid.org/0000-0001-8837-9542
Liang QuanDepartment of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, 510260, Guangzhou, China.ORCID http://orcid.org/0000-0002-0478-4952
Tiansheng ZengDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.
Longzhen CuiTranslational Medicine Center, Huaihe Hospital of Henan University, 475000, Kaifeng, China.
Yan LiuTranslational Medicine Center, Huaihe Hospital of Henan University, 475000, Kaifeng, China.
Chaozeng SiDepartment of Operations and Information Management, China-Japan Friendship Hospital, 100029, Beijing, China.
Wenhui HuangDepartment of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, 510260, Guangzhou, China.
Yifeng DaiDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Jinghong ChenTranslational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, 510260, Guangzhou, China.
Ling LiuDepartment of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, 510260, Guangzhou, China.
Yang JiaoLife Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, 310058, Hangzhou, China.ORCID http://orcid.org/0000-0002-1077-6422
Cong DengTranslational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, 510260, Guangzhou, China.
Ying PangDepartment of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, 510260, Guangzhou, China.
Xu YeDepartment of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, 510260, Guangzhou, China.
Jinlong ShiDepartment of Biomedical Engineering, Chinese PLA General Hospital, 100853, Beijing, China.
Lin FuDepartment of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, 510260, Guangzhou, China. fulin022@126.com.ORCID http://orcid.org/0000-0002-2416-7572

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is a malignant disease of myeloid hematopoietic stem or progenitor cells characterized by abnormal proliferation of primary and immature myeloid cells in bone marrow and peripheral blood. Gene mutation and expression profiles can be used as prognosis predictors for different prognostic subgroups. Secretory carrier-associated membrane proteins (SCAMPs) are a multigenic family with five members and act as cell surface vectors in the post-Golgi recycling pathways in mammals. Nevertheless, the prognostic and clinical influence of SCAMP family has hardly ever been illustrated in AML. In our study, expression patterns of SCAMP family (SCAMP1-5) were analyzed in 155 AML patients which were extracted from the Cancer Genome Atlas database. In chemotherapy, only subgroup, higher SCAMP1 level was significantly associated with longer EFS and OS (all P = 0.002), and SCAMP1 was confirmed to be an independent favorable factor in un-transplanted patients by Multivariate analysis (all P < 0.05). Nevertheless, in the allogeneic hematopoietic stem cell transplantation (allo-HSCT) treatment subgroup, none of the SCAMP genes had any effect on the clinical survival. Our study found that high expression level of SCAMP1 is a favorable prognostic factor in AML, but allo-HSCT may neutralize its prognostic effect.

Indexed as

AdultAgedAged, 80 and overAntineoplastic AgentsDatabases, GeneticFemaleHumansLeukemia, Myeloid, AcuteMaleMiddle AgedPrognosisVesicular Transport ProteinsYoung AdultAntineoplastic AgentsSCAMP1 protein, humanVesicular Transport Proteins

Identifiers

PMID31988488

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.