ArticleNature biomedical engineering2020
On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 158 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 3 pooled it
22.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
158 citing papers in PubMed, 3 syntheses or guidelines pooled it, 284 citations in OpenAlex.
- Modeling Immunity In Vitro: Slices, Chips, and Engineered Tissues.Annual review of biomedical engineering · 2021Pooled it
- Microfluidics and organ-on-a-chip technologies: A systematic review of the methods used to mimic bone marrow.PloS one · 2020Pooled it
- Cell and tissue engineering in lymph nodes for cancer immunotherapy.Advanced drug delivery reviews · 2020Pooled it
- On-chip 3D potency assay for prediction of clinical outcomes for cell therapy candidates for osteoarthritis.Nature communications · 2025Trial
- Ex vivo bone marrow subniches influence the fate of human antibody-secreting cells.Science advances · 2026Article
- A mammary-specific microfluidic device for studying post-radiotherapy vascular-immune cell interactions.bioRxiv : the preprint server for biology · 2026Article
- Next-generation osteosarcoma models for precision medicine.Communications biology · 2026Review
- An immunocompetent bone marrow-on-a-chip model for studying human hematological malignancies and preclinical therapeutic screening.Nature protocols · 2026Review
- Lipid nanoparticles for bone marrow-targeted RNA therapeutics.Journal of nanobiotechnology · 2026Review
- Engineering Organ-on-a-Chip Systems for Cancer Immunotherapy: Strategies and Assay Integration.Bioengineering (Basel, Switzerland) · 2026Review
- Construction Strategies and Advances in Bone Marrow Microphysiological Systems.International journal of molecular sciences · 2026Review
- Article
- Bridging skeletal stem cell diversity and human skeletal modeling.Journal of bone and mineral metabolism · 2026Review
- AutoFlow: an interactive Shiny app for supervised and unsupervised flow cytometry analysis.Bioinformatics (Oxford, England) · 2026Article
- Biomimetic Fibrinogen Nanofiber Scaffolds for Vascular Hematopoietic Stem Cell Niche Engineering.Advanced healthcare materials · 2026Article
- Cell Calcification Models and Their Implications for Medicine and Biomaterial Research.Advanced healthcare materials · 2026Review
- Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs-On-Chips.Advanced biology · 2026Review
- Tailoring human joint-on-a-chip: from biological principles, materials, to disease modeling.Materials today. Bio · 2026Review
- Engineering osteoclast resorption unitsLab on a chip · 2026Article
- Hematopoietic organoids: Opportunities and challenges in modeling human hematopoiesis and diseases in vitro.Stem cell reports · 2026Review
98 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
29 authors at 10 institutions in 3 countries.
David B Chou *Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1659-9308
Viktoras Frismantas *Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Yuka MiltonWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Rhiannon DavidClinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Petar Pop-DamkovDMPK, Oncology R&D, AstraZeneca, Boston, MA, USA.
Douglas FergusonDMPK, Oncology R&D, AstraZeneca, Boston, MA, USA.
Alexander MacDonaldClinical and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, Pharmaceutical Sciences, R&D, AstraZeneca, Cambridge, UK.
Özge Vargel BölükbaşıDana Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4013-6343
Cailin E JoyceDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Liliana S Moreira TeixeiraWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5039-8369
Arianna RechWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Amanda JiangVascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Elizabeth CalamariWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Sasan Jalili-FiroozinezhadWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5004-893X
Brooke A FurlongWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Lucy R O'SullivanWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9641-7315
Carlos F NgWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Youngjae ChoeWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Susan MarquezWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1183-8522
Kasiani C MyersDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Olga K WeinbergDepartment of Pathology, Boston Children's Hospital, Boston, MA, USA.
Robert P HasserjianDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Richard NovakWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Oren LevyWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Rachelle Prantil-BaunWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Carl D NovinaDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Akiko ShimamuraDana Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
Lorna EwartClinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Donald E IngberWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. don.ingber@wyss.harvard.edu.ORCID http://orcid.org/0000-0002-4319-6520
AstraZeneca (United Kingdom) · GBBoston Children's Hospital · USAstraZeneca (United States) · USDana-Farber/Boston Children's Cancer and Blood Disorders Center · USMassachusetts General Hospital · USBroad Institute · USCincinnati Children's Hospital Medical Center · USHarvard University · USLoughborough University · GBUniversity of Lisbon · PT
Funding
MOLECULAR IMMUNOLOGY AND TUMOR BIOLOGYT32CA009216 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI David Michael Langenau · 1985 to 2026
$10.6MStem cells for therapeutics discovery in genetic blood disordersU01HL134812 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI DALEY, GEORGE Q, LIPTON, JEFFREY M · 2016 to 2022
$8.3MTranslational Studies of Inherited Marrow Failure and Myelodysplastic SyndromesR24DK099808 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ABKOWITZ, JANIS L, EBERT, BENJAMIN LEVINE · 2013 to 2017
$8.2MSystems Biology of Bone Marrow Failure and MDS for Precision MedicineRC2DK122533 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI FIGUEROA, MARIA EUGENIA, FLEMING, MARK D · 2019 to 2023
$6.4MA novel program of ubiquitination in global remodeling of the erythroid proteomeR01HL125710 · NHLBI · HARVARD MEDICAL SCHOOL · PI FINLEY, DANIEL J, FLEMING, MARK D · 2015 to 2018
$1.9MDysregulated microRNA function in diamond blackfan anemiaR01DK102165 · NIDDK · DANA-FARBER CANCER INST · PI NOVINA, CARL D · 2013 to 2016
$1.4MMolecular Genetic Investigation of Pediatric Myelodysplastic SyndromeR24DK094746 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI EBERT, BENJAMIN LEVINE, FLEMING, MARK D · 2012 to 2012
$539kUbiquitination in erythropoiesis and the pathophysiology of anemiaR21HL116210 · NHLBI · HARVARD MEDICAL SCHOOL · PI FINLEY, DANIEL J, FLEMING, MARK D · 2012 to 2013
$477kFDA HHS HHSF223201310079CNCI NIH HHS T32 CA009216NHLBI NIH HHS R01 HL125710NHLBI NIH HHS R21 HL116210NHLBI NIH HHS U01 HL134812NIDDK NIH HHS R01 DK102165NIDDK NIH HHS R24 DK094746NIDDK NIH HHS R24 DK099808NIDDK NIH HHS RC2 DK122533U.S. Department of Defense (United States Department of Defense) W81XWH-14-1-0124
Abstract
The inaccessibility of living bone marrow (BM) hampers the study of its pathophysiology under myelotoxic stress induced by drugs, radiation or genetic mutations. Here, we show that a vascularized human BM-on-a-chip (BM chip) supports the differentiation and maturation of multiple blood cell lineages over 4 weeks while improving CD34
Indexed as
HematopoiesisAnimalsAntigens, CD34Bone MarrowBone Marrow CellsBone Marrow TransplantationCell DifferentiationCell ProliferationCells, CulturedHumansLab-On-A-Chip DevicesMesenchymal Stem CellsMicrofluidicsAntigens, CD34
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.