Evidence map›Paper›PMID 31988393›Full record

ArticleScientific reports2020

Identification of a novel uterine leiomyoma GWAS locus in a Japanese population.

Kensuke Sakai, Chizu Tanikawa, Akira Hirasawa, Tatsuyuki Chiyoda, Wataru Yamagami, Fumio Kataoka, Nobuyuki Susumu, Chikashi Terao, Yoichiro Kamatani, Atsushi Takahashi and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. UTERINE FIBROIDS.Physiological reviews · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Kensuke Sakai *Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Chizu Tanikawa *Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Akira HirasawaKeio University School of Medicine, Department of Obstetrics and Gynecology, Tokyo, Japan.
Tatsuyuki ChiyodaKeio University School of Medicine, Department of Obstetrics and Gynecology, Tokyo, Japan.
Wataru YamagamiKeio University School of Medicine, Department of Obstetrics and Gynecology, Tokyo, Japan.
Fumio KataokaKeio University School of Medicine, Department of Obstetrics and Gynecology, Tokyo, Japan.
Nobuyuki SusumuInternational University of Health and Welfare School of Medicine, Department of Obstetrics and Gynecology, Chiba, Japan.
Chikashi TeraoRIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Yoichiro KamataniRIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Atsushi TakahashiRIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Yukihide MomozawaRIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Makoto HirataLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Nobuo FuseTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Takako Takai-IgarashiTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Atsushi ShimizuIwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.
Akimune FukushimaIwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.
Aya KadotaDepartment of Health Science, Shiga University of Medical Science, Shiga, Japan.
Kokichi ArisawaDepartment of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Hiroaki IkezakiDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka, Japan.
Kenji WakaiDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan.
Taiki YamajiDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Norie SawadaDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Motoki IwasakiDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Shoichiro TsuganeCenter for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Daisuke AokiKeio University School of Medicine, Department of Obstetrics and Gynecology, Tokyo, Japan.
Koichi MatsudaLaboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan. kmatsuda@edu.k.u-tokyo.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uterine leiomyoma is one of the most common gynaecologic benign tumours, but its genetic basis remains largely unknown. Six previous GWAS identified 33 genetic factors in total. Here, we performed a two-staged GWAS using 13,746 cases and 70,316 controls from the Japanese population, followed by a replication analysis using 3,483 cases and 4,795 controls. The analysis identified 9 significant loci, including a novel locus on 12q23.2 (rs17033114, P = 6.12 × 10

Indexed as

AdultAgedAged, 80 and overAllelesCohort StudiesFemaleGenetic LociGenome-Wide Association StudyGenotypeHumansJapanLeiomyomaMiddle AgedMutationPolymorphism, Single NucleotideReal-Time Polymerase Chain Reaction

Identifiers

PMID31988393
PMCPMC6985131

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.