Evidence map›Paper›PMID 31988323›Full record

ArticleNature communications2020

Lymphatic endothelial cells prime naïve CD8

Efthymia Vokali, Shann S Yu, Sachiko Hirosue, Marcela Rinçon-Restrepo, Fernanda V Duraes, Stefanie Scherer, Patricia Corthésy-Henrioud, Witold W Kilarski, Anna Mondino, Dietmar Zehn and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Controlling timing and location in vaccines.Advanced drug delivery reviews · 2020
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Linking tumour angiogenesis and tumour immunity.Nature reviews. Immunology · 2026
    Review
  6. A Dapl1Science advances · 2025
    Article
  7. Theranostics · 2025
    Article
  8. Leukocyte-lymphatic intersections during cardiac inflammation.Journal of molecular and cellular cardiology · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Efthymia Vokali *Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Shann S Yu *Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-4461-793X
Sachiko HirosueInstitute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Marcela Rinçon-RestrepoInstitute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Fernanda V DuraesDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Stefanie SchererSwiss Vaccine Research Institute, Epalinges, Switzerland.
Patricia Corthésy-HenrioudInstitute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Witold W KilarskiInstitute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-0734-4749
Anna MondinoDivision of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.
Dietmar ZehnSwiss Vaccine Research Institute, Epalinges, Switzerland.ORCID http://orcid.org/0000-0003-1393-8527
Stéphanie HuguesDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Melody A SwartzInstitute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. melodyswartz@uchicago.edu.ORCID http://orcid.org/0000-0001-5484-1903

Funding

Probing cellular, molecular and biomechanical barriers to immunotherapy in the tumor microenvironment with organotypic in vitro models of the tumor-lympho-immune interfaceR01CA253248 · NCI · UNIVERSITY OF CHICAGO · PI SWARTZ, MELODY ANN · 2021 to 2025
$2.8M
Paradoxical roles of tumor lymphangiogenesis on tumor immunity and implications for immunotherapy - Resubmission 01R01CA219304 · NCI · UNIVERSITY OF CHICAGO · PI SWARTZ, MELODY ANN · 2018 to 2022
$1.8M
NCI NIH HHS R01 CA219304NCI NIH HHS R01 CA253248
6 · The paper itself

Abstract

Lymphatic endothelial cells (LECs) chemoattract naïve T cells and promote their survival in the lymph nodes, and can cross-present antigens to naïve CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesCell ProliferationEndothelial CellsGene Expression ProfilingImmunologic MemoryMice, Inbred C57BLMice, Transgenic

Identifiers

PMID31988323
PMCPMC6985113

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.