ArticleThe Journal of biological chemistry2020
A nicotinamide phosphoribosyltransferase-GAPDH interaction sustains the stress-induced NMN/NAD
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Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- GAPDH nuclear signaling regulates neutrophil migration and inflammatory skin responses.Research square · 2026Article
- Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy.Journal of medicinal chemistry · 2026Article
- Native chromatome profiling reveals hundreds of metabolic enzymes in the nucleus across tissues.Nature communications · 2026Article
- Class 1 Sugar Beet Phytoglobin Shows Strong Affinity to Glyceraldehyde-3-Phosphate Dehydrogenase and DNA In Vitro.International journal of molecular sciences · 2025Article
- Impact of glycolysis enzymes and metabolites in regulating DNA damage repair in tumorigenesis and therapy.Cell communication and signaling : CCS · 2025Review
- Pathobiochemistry of Aging and Neurodegeneration: Deregulation of NAD+ Metabolism in Brain Cells.Biomolecules · 2024Review
- Dangua Fang regulating tricarboxylic acid cycle and respiratory chain and its mechanism in diabetic rats.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer.Journal for immunotherapy of cancer · 2023Article
- Targeting NADFrontiers in immunology · 2023Review
- Sirtuin deficiency and the adverse effects of fructose and uric acid synthesis.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Review
- β-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice.Journal of inflammation research · 2021Article
- The Extracellular NADome Modulates Immune Responses.Frontiers in immunology · 2021Review
- Metabolic Fuel for Epigenetic: Nuclear Production Meets Local Consumption.Frontiers in genetics · 2021Review
- NAMPT Over-Expression Recapitulates the BRAF Inhibitor Resistant Phenotype Plasticity in Melanoma.Cancers · 2020Article
- Location, Location, Location: Compartmentalization of NADTrends in biochemical sciences · 2020Review
- Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy.Frontiers in pharmacology · 2020Review
- NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation.Frontiers in oncology · 2020Review
Corrections and comments
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Authors and funding
25 authors at 8 institutions in 4 countries.
Ambra A GrollaDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy.
Riccardo MiggianoDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy.
Daniele Di MarinoDepartment of Life and Environmental Sciences, New York-Marche Structural Biology Center (NY-MaSBiC), Polytechnic University of Marche, Via Brecce Bianche, 60131 Ancona, Italy.
Michele BianchiDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy.
Alessandro GoriIstituto di Chimica del Riconoscimento Molecolare (ICRM-CNR), via Mario Bianco 9, 20131 Milano, Italy.
Giuseppe OrsomandoDepartment of Clinical Sciences (DISCO), Section of Biochemistry, Polytechnic University of Marche, Via Ranieri 67, 60128 Ancona, Italy.
Federica GaudinoDepartment of Medical Sciences, University of Turin, Via Nizza 52, 10126 Turin, Italy.
Ubaldina GalliDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy.
Erika Del GrossoDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy.
Francesca MazzolaDepartment of Clinical Sciences (DISCO), Section of Biochemistry, Polytechnic University of Marche, Via Ranieri 67, 60128 Ancona, Italy.
Carlo AngelettiDepartment of Clinical Sciences (DISCO), Section of Biochemistry, Polytechnic University of Marche, Via Ranieri 67, 60128 Ancona, Italy.
Martina GuarneriDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy.
Simone TorrettaDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy.
Marta CalabròDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy.
Sara BoumyaDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy.
Xiaorui FanDepartment of Biological Chemistry, UCLA, Los Angeles, California 90095.
Giorgia ColomboDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy.
Cristina TravelliDepartment of Pharmaceutical Sciences, University of Pavia, Via Taramelli 12/14, 27100 Pavia, Italy.
Francesca RocchioDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy.
Eleonora AronicaAmsterdam UMC, University of Amsterdam, Department of (Neuro)Pathology, Amsterdam Neuroscience, 1001 NK Amsterdam, The Netherlands.
James A WohlschlegelDepartment of Biological Chemistry, UCLA, Los Angeles, California 90095.
Silvia DeaglioDepartment of Medical Sciences, University of Turin, Via Nizza 52, 10126 Turin, Italy; Italian Institute for Genomic Medicine, Via Nizza 52, 10126 Turin, Italy.
Menico RizziDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy.
Armando A GenazzaniDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy. Electronic address: armando.genazzani@uniupo.it.
Silvia GaravagliaDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy. Electronic address: silvia.garavaglia@uniupo.it.
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITMarche Polytechnic University · ITUniversity of California, Los Angeles · USAmsterdam Neuroscience · NLInstitute of Chemistry of Molecular Recognition · ITItalian institute for Genomic Medicine · ITUniversity of Pavia · ITUniversity of Turin · IT
Funding
UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7MProteolytic Control of Iron Metabolism by the Ubiquitin Ligase FBXL5R01GM089778 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOHLSCHLEGEL, JAMES AKIRA · 2010 to 2023
$4.0MBiogenesis of Extramitochondrial Iron-Sulfur Proteins in EukaryotesR01GM112763 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOHLSCHLEGEL, JAMES AKIRA · 2015 to 2018
$982kNIGMS NIH HHS R01 GM089778NIGMS NIH HHS R01 GM112763NIGMS NIH HHS T32 GM007185
Abstract
All cells require sustained intracellular energy flux, which is driven by redox chemistry at the subcellular level. NAD
Indexed as
Stress, PhysiologicalAnimalsCell Line, TumorCell NucleusGlyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)HeLa CellsHumansKineticsMelanoma, ExperimentalMiceNADNicotinamide MononucleotideNicotinamide PhosphoribosyltransferaseNIH 3T3 CellsProtein BindingProtein MultimerizationGlyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)NADNicotinamide MononucleotideNicotinamide Phosphoribosyltransferasecell stressGAPDHmelanomametabolismNAD biosynthesisNAD compartmentalizationNAMPTnicotinamide adenine dinucleotide (NAD)nicotinamide mononucleotide (NMN)NMN/NAD+ salvage pathwaynucleusprotein-protein interactionredox cycling
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.