Evidence map›Paper›PMID 31988193›Full record

ArticleGenetics2020

A Cell Fate Switch in the

Mark Hintze, Sneha L Koneru, Sophie P R Gilbert, Dimitris Katsanos, Julien Lambert, Michalis Barkoulas

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. UBR-5 and UBE2D mediate timely exit from stem fate via destabilization of poly(A)-binding protein PABP-2 in cell state transition.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. A PAX6-regulated receptor tyrosine kinase pairs with a pseudokinase to activate immune defense upon oomycete recognition inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mark HintzeDepartment of Life Sciences, Imperial College, London, SW7 2AZ, UK.
Sneha L KoneruDepartment of Life Sciences, Imperial College, London, SW7 2AZ, UK.
Sophie P R GilbertDepartment of Life Sciences, Imperial College, London, SW7 2AZ, UK.
Dimitris KatsanosDepartment of Life Sciences, Imperial College, London, SW7 2AZ, UK.
Julien LambertDepartment of Life Sciences, Imperial College, London, SW7 2AZ, UK.
Michalis BarkoulasDepartment of Life Sciences, Imperial College, London, SW7 2AZ, UK m.barkoulas@imperial.ac.uk.ORCID 0000-0003-1974-7668
Imperial College London · GB

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Populations often display consistent developmental phenotypes across individuals despite inevitable biological stochasticity. Nevertheless, developmental robustness has limits, and systems can fail upon change in the environment or the genetic background. We use here the seam cells, a population of epidermal stem cells in

Indexed as

Asymmetric Cell DivisionCell LineageGenetic VariationWnt Signaling PathwayAnimalsCaenorhabditis elegansEpithelial CellsHeat-Shock ResponseStem CellsC. eleganscryptic genetic variationepidermisrobustnessseam cellsstem celltemperatureV6pappaV6papppWnt pathway

Identifiers

PMID31988193
PMCPMC7153939
OpenAlexW3003997573

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.