Evidence map›Paper›PMID 31988186›Full record

ArticleDevelopment (Cambridge, England)2020

The myeloid lineage is required for the emergence of a regeneration-permissive environment following

Can Aztekin, Tom W Hiscock, Richard Butler, Francisco De Jesús Andino, Jacques Robert, John B Gurdon, Jerome Jullien

Open access · hybridAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 44 citations in OpenAlex.

  1. Commensal skin bacteria interact with the innate immune system to promote tail regeneration in Xenopus laevis tadpoles.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Article
  2. Article
  3. Putative muscle stem cells promoteProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Prdx6 regulatesAnimal cells and systems · 2025
    Article
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  7. Review
  8. Article
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  11. An improved method for whole-mountFrontiers in cell and developmental biology · 2024
    Article
  12. Article
  13. Article
  14. The amphibian immune system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  15. Article
  16. Article
  17. Isolation and Characterization of Peritoneal Macrophages from Salamanders.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  18. Transposon control as a checkpoint for tissue regeneration.Development (Cambridge, England) · 2022
    Article
  19. To regenerate or not to regenerate: Vertebrate model organisms of regeneration-competency and -incompetency.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022
    Review
  20. Manipulating the microbiome alters regenerative outcomes in Xenopus laevis tadpoles via lipopolysaccharide signalling.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Can AztekinWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, CB1 2QN, UK ca477@cam.ac.uk jj256@gurdon.cam.ac.uk.ORCID 0000-0002-6544-9752
Tom W HiscockWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, CB1 2QN, UK.
Richard ButlerWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, CB1 2QN, UK.
Francisco De Jesús AndinoDepartment of Microbiology & Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Jacques RobertDepartment of Microbiology & Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
John B GurdonWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, CB1 2QN, UK.
Jerome JullienWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, CB1 2QN, UK ca477@cam.ac.uk jj256@gurdon.cam.ac.uk.ORCID 0000-0002-7868-0021
University of Cambridge · GBUniversity of Rochester Medical Center · USInserm · FR

Funding

A Xenopus Laevis Research Resource for ImmunologyR24AI059830 · NIAID · UNIVERSITY OF ROCHESTER · PI JACQUES Robert · 2004 to 2026
$7.7M
Cancer Research UK C6946/A14492NIAID NIH HHS R24 AI059830Wellcome TrustWellcome Trust 092096/Z/10/ZWellcome Trust 101050/Z/13/ZWellcome Trust 105031/D/14/Z
6 · The paper itself

Abstract

Regeneration-competent vertebrates are considered to suppress inflammation faster than non-regenerating ones. Hence, understanding the cellular mechanisms affected by immune cells and inflammation can help develop strategies to promote tissue repair and regeneration. Here, we took advantage of naturally occurring tail regeneration-competent and -incompetent developmental stages of

Indexed as

AnimalsApoptosisCell LineageExtracellular MatrixGene ExpressionGene Expression Regulation, DevelopmentalImmunosuppressive AgentsLarvaMyeloid CellsRegenerationRegenerative MedicineTailXenopus laevisImmunosuppressive AgentsInflammationMacrophagesMyeloid lineageNeutrophilsTail regenerationXenopus

Identifiers

PMID31988186
PMCPMC7033733
OpenAlexW2999726172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.