Evidence map›Paper›PMID 31988178›Full record

ArticleInfection and immunity2020

Human IgM Inhibits the Formation of Titan-Like Cells in Cryptococcus neoformans.

Nuria Trevijano-Contador, Kaila M Pianalto, Connie B Nichols, Oscar Zaragoza, J Andrew Alspaugh, Liise-Anne Pirofski

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Effects of human immunoglobulin A onMicrobiology spectrum · 2025
    Article
  7. Review
  8. Review
  9. Review
  10. Association of Antibody Immunity With Cryptococcal Antigenemia and Mortality in a South African Cohort With Advanced Human Immunodeficiency Virus Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  11. Open forum infectious diseases · 2022
    Article
  12. Article
  13. Article
  14. Frontiers in cellular and infection microbiology · 2022
    Review
  15. Macrophage Mediated Immunomodulation DuringFrontiers in cellular and infection microbiology · 2022
    Review
  16. Article
  17. Titan Cells and Yeast Forms ofMicroorganisms · 2021
    Article
  18. Article
  19. Associations betweenJournal of fungi (Basel, Switzerland) · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nuria Trevijano-ContadorDivision of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Kaila M PianaltoDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Connie B NicholsDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Oscar ZaragozaMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.
J Andrew AlspaughDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-3009-627X
Liise-Anne PirofskiDivision of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA l.pirofski@einsteinmed.org.
Duke University · USAlbert Einstein College of Medicine · USInstituto de Salud Carlos III · ES

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2M
Coordinated Regulation of Virulence Genes in C. neoformansR01AI074677 · NIAID · DUKE UNIVERSITY · PI ALSPAUGH, ANDREW, WORMLEY, FLOYD L. · 2011 to 2020
$4.0M
Antibodies, B cells and resistance to human cryptococcosisR01AI143453 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI PIROFSKI, LIISE-ANNE · 2019 to 2024
$3.2M
B cell subsets and immunity to cryptococcosisR01AI097096 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI PIROFSKI, LIISE-ANNE · 2012 to 2016
$2.7M
Coordinated Regulation of Virulence Genes in C. neoformansR56AI074677 · NIAID · DUKE UNIVERSITY · PI ALSPAUGH, ANDREW · 2009 to 2010
$608k
120kV Transmission Electron Microscope for a Multi-user Microscopy FacilityS10OD016214 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CONDEELIS, JOHN S · 2014 to 2014
$459k
NCI NIH HHS P30 CA013330NIAID NIH HHS R01 AI074677NIAID NIH HHS R01 AI097096NIAID NIH HHS R01 AI143453NIAID NIH HHS R56 AI074677NIH HHS S10 OD016214
6 · The paper itself

Abstract

Human studies have shown associations between cryptococcal meningitis and reduced IgM memory B cell levels, and studies in IgM- and/or B cell-deficient mice have demonstrated increased

Indexed as

Host-Pathogen InteractionsCryptococcus neoformansHumansImmunoglobulin GImmunoglobulin MImmunologic FactorsVirulenceImmunoglobulin GImmunoglobulin MImmunologic Factorsbeta glucanscapsulecell wallcryptococcosisCryptococcus neoformansIgGIgMIgM memory B cellsnatural antibodiestitan cells

Identifiers

PMID31988178
PMCPMC7093138
OpenAlexW3003753409

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.