ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2020
Outcomes and care practices for preterm infants born at less than 33 weeks' gestation: a quality-improvement study.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04531839 (Improving the Outcome of Very Preterm Infants Using Evidence-based Collaborative Quality Improvement), which is not on this map. Cited by 49 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving the Outcome of Very Preterm Infants Using Evidence-based Collaborative Quality Improvement: A Multi-center Prospective Study
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Prevalence of survival without major morbidity and associated risk factors among very preterm infants: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- PINK1 deficiency exacerbates age-related bone loss in association with enhanced inflammatory adipocyte differentiation.Genes & diseases · 2027Article
- Late childhood and adolescent health outcomes in preterm-born infants during 2004-2012: a population-based cohort study in British Columbia, Canada.Lancet regional health. Americas · 2026Article
- Protocol for the external validation of machine learning models for risk prediction in early-onset preeclampsia: a multicenter prospective cohort study.BMC pregnancy and childbirth · 2026Article
- Total hydrocortisone dosage in extremely low birth weight infants and neurodevelopment up to school age.Pediatric research · 2026Article
- Incidence of psychotic disorders by birth cohort: a population-based cohort study in Ontario, Canada.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- Association of individual and bundled evidence-based practices with adverse outcomes in very preterm infants: a multicenter retrospective study.Frontiers in pediatrics · 2026Article
- Music-based research in neonatal intensive care units requires guidelines grounded in developmental neurology and responsive to the individual needs of preterm infants.Frontiers in psychology · 2026Article
- Golden hour(s) quality improvement protocols and their effect on outcomes in preterm infants ≤ 32 weeks of gestation: a scoping review.BMC pediatrics · 2025Article
- Narrative review of neurodevelopmental and psychiatric complications associated with prematurity.BMC pediatrics · 2025Review
- Article
- Improving UK data on avoidable perinatal brain injury: review of data dictionaries and consultation.Pediatric research · 2025Review
- Association of human resources with outcomes of very preterm infants: a survey-linked retrospective cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Outcomes of Preterm Infants Admitted to Canadian NICUs Before and During the SARS-COV Pandemic.Children (Basel, Switzerland) · 2025Article
- Enhancing Neurodevelopmental Outcomes in Preterm Infants Through the Sensory Development Care Map.Children (Basel, Switzerland) · 2025Article
- Effectiveness of the Educational Technology "Sophia's Story" in Transitional Care and Stimulation of Preterm Infants.Revista brasileira de enfermagem · 2025Article
- Implementing Telemedicine Intervention in Neonatal Intensive Care Units: Augmented Teleconsultation and Real-Time Monitoring Experience.Telemedicine reports · 2025Article
- Surfactant treatment at birth in a contemporary cohort of preterm infants with bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2024Observational
- Association between Neonatal Outcomes and Admission Hypothermia among Very Preterm Infants in Chinese Neonatal Intensive Care Units: A Multicenter Cohort Study.American journal of perinatology · 2024Article
- Antimicrobial utilisation patterns between 2013 and 2022 in Canadian neonates born at less than 33 weeks gestation: a retrospective cohort study.Lancet regional health. Americas · 2024Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Shoo K LeeDepartment of Pediatrics and Maternal-Infant Care Research Centre (Lee), Sinai Health System; Departments of Pediatrics, and Obstetrics and Gynecology, and Dalla Lana School of Public Health (Lee), University of Toronto, Toronto, Ont.; Department of Pediatrics (Beltempo), Montreal Children's Hospital and McGill University Health Centre, Montréal, Que.; Department of Pediatrics (McMillan), IWK Health Centre and Dalhousie University, Halifax, NS; Department of Pediatrics and Child Health (Seshia), Winnipeg Children's Hospital and University of Manitoba, Winnipeg, Man.; Department of Pediatrics, Foothills Medical Centre and University of Calgary (Singhal), Calgary, Alta.; Department of Paediatrics/Neonatology (Dow), Kingston Health Sciences Centre and Queen's University, Kingston, Ont.; Department of Pediatrics (Aziz), Royal Alexandra Hospital and University of Alberta, Edmonton, Alta.; Department of Pediatrics (Piedboeuf), Centre hospitalier universitaire de Québec and Université Laval, Québec, Que.; Department of Pediatrics, Sinai Health System (Shah); Department of Pediatrics, and Institute of Health Policy, Management and Evaluation (Shah), University of Toronto, Toronto, Ont.
Marc BeltempoDepartment of Pediatrics and Maternal-Infant Care Research Centre (Lee), Sinai Health System; Departments of Pediatrics, and Obstetrics and Gynecology, and Dalla Lana School of Public Health (Lee), University of Toronto, Toronto, Ont.; Department of Pediatrics (Beltempo), Montreal Children's Hospital and McGill University Health Centre, Montréal, Que.; Department of Pediatrics (McMillan), IWK Health Centre and Dalhousie University, Halifax, NS; Department of Pediatrics and Child Health (Seshia), Winnipeg Children's Hospital and University of Manitoba, Winnipeg, Man.; Department of Pediatrics, Foothills Medical Centre and University of Calgary (Singhal), Calgary, Alta.; Department of Paediatrics/Neonatology (Dow), Kingston Health Sciences Centre and Queen's University, Kingston, Ont.; Department of Pediatrics (Aziz), Royal Alexandra Hospital and University of Alberta, Edmonton, Alta.; Department of Pediatrics (Piedboeuf), Centre hospitalier universitaire de Québec and Université Laval, Québec, Que.; Department of Pediatrics, Sinai Health System (Shah); Department of Pediatrics, and Institute of Health Policy, Management and Evaluation (Shah), University of Toronto, Toronto, Ont.
Douglas D McMillanDepartment of Pediatrics and Maternal-Infant Care Research Centre (Lee), Sinai Health System; Departments of Pediatrics, and Obstetrics and Gynecology, and Dalla Lana School of Public Health (Lee), University of Toronto, Toronto, Ont.; Department of Pediatrics (Beltempo), Montreal Children's Hospital and McGill University Health Centre, Montréal, Que.; Department of Pediatrics (McMillan), IWK Health Centre and Dalhousie University, Halifax, NS; Department of Pediatrics and Child Health (Seshia), Winnipeg Children's Hospital and University of Manitoba, Winnipeg, Man.; Department of Pediatrics, Foothills Medical Centre and University of Calgary (Singhal), Calgary, Alta.; Department of Paediatrics/Neonatology (Dow), Kingston Health Sciences Centre and Queen's University, Kingston, Ont.; Department of Pediatrics (Aziz), Royal Alexandra Hospital and University of Alberta, Edmonton, Alta.; Department of Pediatrics (Piedboeuf), Centre hospitalier universitaire de Québec and Université Laval, Québec, Que.; Department of Pediatrics, Sinai Health System (Shah); Department of Pediatrics, and Institute of Health Policy, Management and Evaluation (Shah), University of Toronto, Toronto, Ont.
Mary SeshiaDepartment of Pediatrics and Maternal-Infant Care Research Centre (Lee), Sinai Health System; Departments of Pediatrics, and Obstetrics and Gynecology, and Dalla Lana School of Public Health (Lee), University of Toronto, Toronto, Ont.; Department of Pediatrics (Beltempo), Montreal Children's Hospital and McGill University Health Centre, Montréal, Que.; Department of Pediatrics (McMillan), IWK Health Centre and Dalhousie University, Halifax, NS; Department of Pediatrics and Child Health (Seshia), Winnipeg Children's Hospital and University of Manitoba, Winnipeg, Man.; Department of Pediatrics, Foothills Medical Centre and University of Calgary (Singhal), Calgary, Alta.; Department of Paediatrics/Neonatology (Dow), Kingston Health Sciences Centre and Queen's University, Kingston, Ont.; Department of Pediatrics (Aziz), Royal Alexandra Hospital and University of Alberta, Edmonton, Alta.; Department of Pediatrics (Piedboeuf), Centre hospitalier universitaire de Québec and Université Laval, Québec, Que.; Department of Pediatrics, Sinai Health System (Shah); Department of Pediatrics, and Institute of Health Policy, Management and Evaluation (Shah), University of Toronto, Toronto, Ont.
Nalini SinghalDepartment of Pediatrics and Maternal-Infant Care Research Centre (Lee), Sinai Health System; Departments of Pediatrics, and Obstetrics and Gynecology, and Dalla Lana School of Public Health (Lee), University of Toronto, Toronto, Ont.; Department of Pediatrics (Beltempo), Montreal Children's Hospital and McGill University Health Centre, Montréal, Que.; Department of Pediatrics (McMillan), IWK Health Centre and Dalhousie University, Halifax, NS; Department of Pediatrics and Child Health (Seshia), Winnipeg Children's Hospital and University of Manitoba, Winnipeg, Man.; Department of Pediatrics, Foothills Medical Centre and University of Calgary (Singhal), Calgary, Alta.; Department of Paediatrics/Neonatology (Dow), Kingston Health Sciences Centre and Queen's University, Kingston, Ont.; Department of Pediatrics (Aziz), Royal Alexandra Hospital and University of Alberta, Edmonton, Alta.; Department of Pediatrics (Piedboeuf), Centre hospitalier universitaire de Québec and Université Laval, Québec, Que.; Department of Pediatrics, Sinai Health System (Shah); Department of Pediatrics, and Institute of Health Policy, Management and Evaluation (Shah), University of Toronto, Toronto, Ont.
Kimberly DowDepartment of Pediatrics and Maternal-Infant Care Research Centre (Lee), Sinai Health System; Departments of Pediatrics, and Obstetrics and Gynecology, and Dalla Lana School of Public Health (Lee), University of Toronto, Toronto, Ont.; Department of Pediatrics (Beltempo), Montreal Children's Hospital and McGill University Health Centre, Montréal, Que.; Department of Pediatrics (McMillan), IWK Health Centre and Dalhousie University, Halifax, NS; Department of Pediatrics and Child Health (Seshia), Winnipeg Children's Hospital and University of Manitoba, Winnipeg, Man.; Department of Pediatrics, Foothills Medical Centre and University of Calgary (Singhal), Calgary, Alta.; Department of Paediatrics/Neonatology (Dow), Kingston Health Sciences Centre and Queen's University, Kingston, Ont.; Department of Pediatrics (Aziz), Royal Alexandra Hospital and University of Alberta, Edmonton, Alta.; Department of Pediatrics (Piedboeuf), Centre hospitalier universitaire de Québec and Université Laval, Québec, Que.; Department of Pediatrics, Sinai Health System (Shah); Department of Pediatrics, and Institute of Health Policy, Management and Evaluation (Shah), University of Toronto, Toronto, Ont.
Khalid AzizDepartment of Pediatrics and Maternal-Infant Care Research Centre (Lee), Sinai Health System; Departments of Pediatrics, and Obstetrics and Gynecology, and Dalla Lana School of Public Health (Lee), University of Toronto, Toronto, Ont.; Department of Pediatrics (Beltempo), Montreal Children's Hospital and McGill University Health Centre, Montréal, Que.; Department of Pediatrics (McMillan), IWK Health Centre and Dalhousie University, Halifax, NS; Department of Pediatrics and Child Health (Seshia), Winnipeg Children's Hospital and University of Manitoba, Winnipeg, Man.; Department of Pediatrics, Foothills Medical Centre and University of Calgary (Singhal), Calgary, Alta.; Department of Paediatrics/Neonatology (Dow), Kingston Health Sciences Centre and Queen's University, Kingston, Ont.; Department of Pediatrics (Aziz), Royal Alexandra Hospital and University of Alberta, Edmonton, Alta.; Department of Pediatrics (Piedboeuf), Centre hospitalier universitaire de Québec and Université Laval, Québec, Que.; Department of Pediatrics, Sinai Health System (Shah); Department of Pediatrics, and Institute of Health Policy, Management and Evaluation (Shah), University of Toronto, Toronto, Ont.
Bruno PiedboeufDepartment of Pediatrics and Maternal-Infant Care Research Centre (Lee), Sinai Health System; Departments of Pediatrics, and Obstetrics and Gynecology, and Dalla Lana School of Public Health (Lee), University of Toronto, Toronto, Ont.; Department of Pediatrics (Beltempo), Montreal Children's Hospital and McGill University Health Centre, Montréal, Que.; Department of Pediatrics (McMillan), IWK Health Centre and Dalhousie University, Halifax, NS; Department of Pediatrics and Child Health (Seshia), Winnipeg Children's Hospital and University of Manitoba, Winnipeg, Man.; Department of Pediatrics, Foothills Medical Centre and University of Calgary (Singhal), Calgary, Alta.; Department of Paediatrics/Neonatology (Dow), Kingston Health Sciences Centre and Queen's University, Kingston, Ont.; Department of Pediatrics (Aziz), Royal Alexandra Hospital and University of Alberta, Edmonton, Alta.; Department of Pediatrics (Piedboeuf), Centre hospitalier universitaire de Québec and Université Laval, Québec, Que.; Department of Pediatrics, Sinai Health System (Shah); Department of Pediatrics, and Institute of Health Policy, Management and Evaluation (Shah), University of Toronto, Toronto, Ont.
Prakesh S ShahDepartment of Pediatrics and Maternal-Infant Care Research Centre (Lee), Sinai Health System; Departments of Pediatrics, and Obstetrics and Gynecology, and Dalla Lana School of Public Health (Lee), University of Toronto, Toronto, Ont.; Department of Pediatrics (Beltempo), Montreal Children's Hospital and McGill University Health Centre, Montréal, Que.; Department of Pediatrics (McMillan), IWK Health Centre and Dalhousie University, Halifax, NS; Department of Pediatrics and Child Health (Seshia), Winnipeg Children's Hospital and University of Manitoba, Winnipeg, Man.; Department of Pediatrics, Foothills Medical Centre and University of Calgary (Singhal), Calgary, Alta.; Department of Paediatrics/Neonatology (Dow), Kingston Health Sciences Centre and Queen's University, Kingston, Ont.; Department of Pediatrics (Aziz), Royal Alexandra Hospital and University of Alberta, Edmonton, Alta.; Department of Pediatrics (Piedboeuf), Centre hospitalier universitaire de Québec and Université Laval, Québec, Que.; Department of Pediatrics, Sinai Health System (Shah); Department of Pediatrics, and Institute of Health Policy, Management and Evaluation (Shah), University of Toronto, Toronto, Ont. prakeshkumar.shah@sinaihealthsystem.ca.
Evidence-based Practice for Improving Quality Investigators
Dalhousie University · CAIzaak Walton Killam Health Centre · CAMcGill University Health Centre · CASinai Health System · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreterm birth is the leading cause of morbidity and mortality in children younger than 5 years. We report the changes in neonatal outcomes and care practices among very preterm infants in Canada over 14 years within a national, collaborative, continuous quality-improvement program.
methodsWe retrospectively studied infants born at 23-32 weeks' gestation who were admitted to tertiary neonatal intensive care units that participated in the Evidence-based Practice for Improving Quality program in the Canadian Neonatal Network from 2004 to 2017. The primary outcome was survival without major morbidity during the initial hospital admission. We quantified changes using process-control charts in 6-month intervals to identify special-cause variations, adjusted regression models for yearly changes, and interrupted time series analyses.
resultsThe final study population included 50 831 infants. As a result of practice changes, survival without major morbidity increased significantly (56.6% [669/1183] to 70.9% [1424/2009]; adjusted odds ratio [OR] 1.08, 95% confidence interval [CI] 1.06-1.10, per year) across all gestational ages. Survival of infants born at 23-25 weeks' gestation increased (70.8% [97/137] to 74.5% [219/294]; adjusted OR 1.03, 95% CI 1.02-1.05, per year). Changes in care practices included increased use of antenatal steroids (83.6% [904/1081] to 88.1% [1747/1983]), increased rates of normothermia at admission (44.8% [520/1160] to 67.5% [1316/1951]) and reduced use of pulmonary surfactant (52.8% [625/1183] to 42.7% [857/2009]).
interpretationNetwork-wide quality-improvement activities that include better implementation of optimal care practices can yield sustained improvement in survival without morbidity in very preterm infants.
Indexed as
Quality ImprovementCanadaFemaleGestational AgeHumansInfant, NewbornInfant, PrematureIntensive Care, NeonatalMaleOutcome and Process Assessment, Health CareProgram EvaluationQuality Indicators, Health CareRetrospective StudiesSurvival Analysis
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Registered trials
NCT04531839ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.