Evidence map›Paper›PMID 31988103›Full record

ArticleAntimicrobial agents and chemotherapy2020

Overexpression of RamA, Which Regulates Production of the Multidrug Resistance Efflux Pump AcrAB-TolC, Increases Mutation Rate and Influences Drug Resistance Phenotype.

Elizabeth M Grimsey, Natasha Weston, Vito Ricci, Jack W Stone, Laura J V Piddock

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Article
  3. A novel mutation ofMicrobiology spectrum · 2025
    Article
  4. Review
  5. Frontiers in microbiology · 2025
    Article
  6. Characterization ofFrontiers in cellular and infection microbiology · 2025
    Article
  7. Article
  8. Journal of bacteriology · 2024
    Article
  9. Biocide resistance inInfection prevention in practice · 2024
    Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Acetylome and Succinylome Profiling ofAntibiotics (Basel, Switzerland) · 2022
    Article
  19. Article
  20. RamAp Is an Efflux Pump Regulator Carried by an IncHI2 Plasmid.Antimicrobial agents and chemotherapy · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elizabeth M Grimsey *Antimicrobials Research Group, Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0003-1211-2598
Natasha Weston *Antimicrobials Research Group, Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
Vito RicciAntimicrobials Research Group, Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
Jack W StoneAntimicrobials Research Group, Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
Laura J V PiddockAntimicrobials Research Group, Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom l.j.v.piddock@bham.ac.uk.ORCID 0000-0003-1460-473X

Funding

Medical Research Council MR/N017846/1Medical Research Council MR/P022596/1
6 · The paper itself

Abstract

In

Indexed as

Mutation RateATP-Binding Cassette, Sub-Family C ProteinsBacterial ProteinsCiprofloxacinDrug Resistance, Multiple, BacterialGene Expression Regulation, BacterialMembrane Transport ProteinsMicrobial Sensitivity TestsPhenotypeSalmonella typhimuriumTrans-ActivatorsATP-Binding Cassette, Sub-Family C ProteinsBacterial ProteinsCiprofloxacinMembrane Transport ProteinsRamA protein, Salmonella typhimuriumTrans-ActivatorsAcrBmultidrug resistancemutation rateRamASoxR

Identifiers

PMID31988103
PMCPMC7179326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.