Evidence map›Paper›PMID 31987972›Full record

Trial reportInternational journal of radiation oncology, biology, physics2020

Preoperative Prediction of Pathologic Response to Neoadjuvant Chemoradiotherapy in Patients With Esophageal Cancer Using

Alicia S Borggreve, Lucas Goense, Peter S N van Rossum, Sophie E Heethuis, Richard van Hillegersberg, Jan J W Lagendijk, Marnix G E H Lam, Astrid L H M W van Lier, Stella Mook, Jelle P Ruurda and 9 more

Open access · greenAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in International journal of radiation oncology, biology, physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 5 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 5 syntheses or guidelines pooled it, 81 citations in OpenAlex.

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  12. European journal of nuclear medicine and molecular imaging · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Alicia S BorggreveDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht University, the Netherlands; Department of Surgery, University Medical Center Utrecht, Utrecht University, the Netherlands.
Lucas GoenseDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht University, the Netherlands; Department of Surgery, University Medical Center Utrecht, Utrecht University, the Netherlands.
Peter S N van RossumDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht University, the Netherlands.
Sophie E HeethuisDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht University, the Netherlands.
Richard van HillegersbergDepartment of Surgery, University Medical Center Utrecht, Utrecht University, the Netherlands.
Jan J W LagendijkDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht University, the Netherlands.
Marnix G E H LamDepartment of Nuclear Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.
Astrid L H M W van LierDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht University, the Netherlands.
Stella MookDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht University, the Netherlands.
Jelle P RuurdaDepartment of Surgery, University Medical Center Utrecht, Utrecht University, the Netherlands.
Marco van VulpenProton Therapy Center Delft, the Netherlands.
Francine E M VonckenDepartment of Radiation Oncology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Berthe M P AlemanDepartment of Radiation Oncology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Annemarieke Bartels-RuttenDepartment of Radiology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Jingfei MaDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Penny FangDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Benjamin C MusallDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Steven H LinDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Gert J MeijerDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht University, the Netherlands. Electronic address: G.J.Meijer@umcutrecht.nl.
University Medical Center Utrecht · NLThe University of Texas MD Anderson Cancer Center · USUtrecht University · NLThe Netherlands Cancer Institute · NL

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

purposeAccurate preoperative prediction of pathologic response to neoadjuvant chemoradiotherapy (nCRT) in patients with esophageal cancer could enable omission of esophagectomy in patients with a pathologic complete response (pCR). This study aimed to evaluate the individual and combined value of METHODS AND MATERIALS: In this multicenter prospective study, patients scheduled to receive nCRT followed by esophagectomy for esophageal cancer underwent

resultspCR was found in 26.1% of 69 patients. Relative changes in

conclusionsChanges on

Indexed as

ChemoradiotherapyDiffusion Magnetic Resonance ImagingFluorodeoxyglucose F18Neoadjuvant TherapyPositron Emission Tomography Computed TomographyEsophageal NeoplasmsFemaleHumansMaleMiddle AgedPreoperative PeriodSurvival AnalysisFluorodeoxyglucose F18

Identifiers

PMID31987972
PMCPMC7103753
OpenAlexW3002735034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.