ArticleExperimental gerontology2020
Primordial follicle reserve, DNA damage and macrophage infiltration in the ovaries of the long-living Ames dwarf mice.
Article in Experimental gerontology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Timing and duration of calorie restriction determine its impact on ovarian aging in female mice.npj aging · 2025Article
- Reproductive Ageing: Inflammation, immune cells, and cellular senescence in the aging ovary.Reproduction (Cambridge, England) · 2024Review
- The role of cellular senescence in ovarian aging.npj aging · 2024Review
- A single-cell atlas of the aging mouse ovary.Nature aging · 2024Article
- Mechanisms of ovarian aging in women: a review.Journal of ovarian research · 2023Review
- Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome.Journal of visualized experiments : JoVE · 2023Article
- The Clinical Application of Growth Hormone and Its Biological and Molecular Mechanisms in Assisted Reproduction.International journal of molecular sciences · 2022Review
- Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary.GeroScience · 2022Article
- Mild calorie restriction, but not 17α-estradiol, extends ovarian reserve and fertility in female mice.Experimental gerontology · 2022Article
- The Interconnections Between Somatic and Ovarian Aging in Murine Models.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Review
- Growth Hormone and Aging: New Findings.The world journal of men's health · 2021Review
- Growth hormone and aging.Reviews in endocrine & metabolic disorders · 2021Review
- Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion.Mechanisms of ageing and development · 2021Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
The aim of this study was to evaluate the effect of growth hormone (GH) deficiency in primordial follicle reserve, DNA damage and macrophage infiltration in the ovaries of young mice. Ovaries from six-month-old GH-deficient Ames Dwarf (df/df) and Normal (N/df) mice were used. The number of primordial follicles was higher in df/df mice (p = 0.0026). Also, df/df mice had a lower number of primary (p = 0.023), secondary (p = 0.0052) and tertiary (p = 0.019) follicles. These findings indicate a slower rate of primordial follicle activation in df/df mice. Female df/df mice had decreased γH2AX foci intensity in oocytes of primordial (p = 0.015) and primary (p = 0.0004) follicles compared to N/df mice. Also, df/df mice had reduced γH2AX intensity in granulosa cells of primordial (p = 0.0002) and primary (p < 0.0001) follicles. Overall, this indicate to us that df/df mice accumulate less DNA damage in the ovarian reserve compared to N/df mice. Additionally, macrophage infiltration was also reduced in ovaries of df/df mice compared to N/df mice (p = 0.033). Interestingly, df/df mice had a reduced number of granulosa cells around primordial (p = 0.0024) and primary (p = 0.007) follicles compared to N/df mice. Also, df/df mice had a small diameter of primordial follicle nuclei (p = 0.0093), secondary follicle oocyte (p = 0.046) and tertiary follicle (p = 0.012). This points to the role of granulosa cell proliferation and oocyte growth for primordial follicle activation. The current study points to the role of the GH/IGF-I axis in extending lifespan of reproductive health, along with maintenance of oocyte DNA integrity and reduced ovarian inflammation.
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