Evidence map›Paper›PMID 31987863›Full record

ArticleNeuropharmacology2020

Adjunctive effect of the serotonin 5-HT

Salvador Sierra, Kumiko M Lippold, David L Stevens, Justin L Poklis, William L Dewey, Javier González-Maeso

Open access · greenAbstract read
In one paragraph

Article in Neuropharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Sex-specific role for serotonin 5-HTNeuropharmacology · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Salvador SierraDepartment of Physiology & Biophysics Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.
Kumiko M LippoldDepartment of Pharmacology & Toxicology Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.
David L StevensDepartment of Pharmacology & Toxicology Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.
Justin L PoklisDepartment of Pharmacology & Toxicology Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.
William L DeweyDepartment of Pharmacology & Toxicology Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.
Javier González-MaesoDepartment of Physiology & Biophysics Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA. Electronic address: javier.maeso@vcuhealth.org.
Virginia Commonwealth University · US

Funding

TRAINING IN THE PHARMACOLOGY OF ABUSED DRUGST32DA007027 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI William L. Dewey · 1985 to 2026
$14.7M
VCU Center for Drug Addiction ResearchP30DA033934 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Matthew Sean Halquist · 2014 to 2026
$13.8M
Structure and function of the 5HT2A/mGluR2 complex in schizophreniaR01MH084894 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI Javier Gonzalez-Maeso · 2009 to 2026
$6.8M
Mechanisms of Ethanol's Reversal of Opioid ToleranceR01DA036975 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI AKBARALI, HAMID I, DEWEY, WILLIAM L. · 2014 to 2018
$2.3M
Preclinical role of HDAC2 in mGlu2-dependent schizophrenia treatmentR01MH111940 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI GONZÁLEZ-MAESO, JAVIER · 2017 to 2021
$1.5M
NIDA NIH HHS P30 DA033934NIDA NIH HHS R01 DA036975NIDA NIH HHS T32 DA007027NIMH NIH HHS R01 MH084894NIMH NIH HHS R01 MH111940
6 · The paper itself

Abstract

Opioid-sparing adjuncts are treatments that aim to reduce the overall dose of opioids needed to achieve analgesia, hence decreasing the burden of side effects through alternative mechanisms of action. Lorcaserin is a serotonin 5-HT

Indexed as

Receptor, Serotonin, 5-HT2CAminopyridinesAnalgesicsAnalgesics, OpioidAnimalsBenzazepinesDose-Response Relationship, DrugDrug Therapy, CombinationIndolesInjections, SpinalMaleMicePain MeasurementSerotonin 5-HT2 Receptor AgonistsSerotonin 5-HT2 Receptor Antagonists6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indolineAminopyridinesAnalgesicsAnalgesics, OpioidBenzazepinesIndoleslorcaserinReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor AgonistsSerotonin 5-HT2 Receptor AntagonistsAnalgesiaAntinociceptionFentanylG protein-coupled receptor (GPCR)LorcaserinMorphineOpioid receptorOxycodonePainSerotonin 5-HT2C receptor

Identifiers

PMID31987863
PMCPMC7080563
OpenAlexW3001883659

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.