Evidence map›Paper›PMID 31987846›Full record

ArticleThe Journal of allergy and clinical immunology2020

Severe combined immunodeficiency caused by inositol-trisphosphate 3-kinase B (ITPKB) deficiency.

Abduarahman Almutairi, Jacqueline G Wallace, Faris Jaber, Mohammed F Alosaimi, Jennifer Jones, Mohamed T H Sallam, M H Elnagdy, Janet Chou, Ali Sobh, Raif S Geha

Open access · greenAbstract readCase ReportsLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Updates on new monogenic inborn errors of immunity.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Abduarahman AlmutairiDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Jacqueline G WallaceDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Faris JaberDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Mohammed F AlosaimiDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass; Department of Pediatrics, Allergy and Immunology Division, King Saud University, Riyadh, Saudi Arabia.
Jennifer JonesDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Mohamed T H SallamDepartment of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
M H ElnagdyDepartment of Medical Biochemistry, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Janet ChouDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Ali SobhDepartment of Pediatrics, Mansoura University Children's Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Raif S GehaDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass. Electronic address: raif.geha@childrens.harvard.edu.
Boston Children's Hospital · USAin Shams University · EGChildren's Hospital Mansoura University · EGMansoura University · EG

Funding

Mechanisms of a Novel Combined Immunodeficiency Caused by a Homozygous Mutation in COPG1R01AI139633 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI GEHA, RAIF SALIM · 2018 to 2022
$3.1M
NIAID NIH HHS R01 AI139633
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell LineChildFemaleHEK293 CellsHumansImmunoglobulin GLymphopeniaMicePhosphotransferases (Alcohol Group Acceptor)Severe Combined ImmunodeficiencyImmunoglobulin GInositol 1,4,5-trisphosphate 3-kinasePhosphotransferases (Alcohol Group Acceptor)

Identifiers

PMID31987846
PMCPMC11520679
OpenAlexW3001071957

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.