Evidence map›Paper›PMID 31987474›Full record

ArticleLife sciences in space research2020

Lung cancer progression using fast switching multiple ion beam radiation and countermeasure prevention.

Krishna Luitel, Sang Bum Kim, Summer Barron, James A Richardson, Jerry W Shay

Open access · greenAbstract read
In one paragraph

Article in Life sciences in space research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Krishna LuitelDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Sang Bum KimDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Sevrance Biomedical Research Institute, Yonsei University College of Medicine, Seoul 03722, South Korea.
Summer BarronDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
James A RichardsonDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jerry W ShayDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: jerry.shay@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · USYonsei University · KR

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Sandi Leigh Pruitt · 2010 to 2026
$53.7M
Cell Biology Research Improvements and RenovationsC06RR030414 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI FITZ, JOHN GREGORY · 2010 to 2010
$15.0M
Cancer Biology Training GrantT32CA124334 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI SHAY, JERRY WILLIAM · 2007 to 2021
$5.3M
NASA NNX15AI21GNASA NNX16AE08GNCI NIH HHS P30 CA142543NCI NIH HHS T32 CA124334NCRR NIH HHS C06 RR030414
6 · The paper itself

Abstract

Most of the research in understanding space radiation-induced cancer progression and risk assessment has been performed using mono-energetic single-ion beams. However, the space radiation environment consists of a wide variety of ion species with a various range of energies. Using the fast beam switching technology developed at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL), ion species can be switched rapidly allowing investigators to use multiple ions with different energies to simulate more closely the radiation environment found in space. Here, we exposed a lung cancer susceptible mouse model (K-ras

Indexed as

AnimalsDisease Models, AnimalFemaleLung NeoplasmsMaleMalondialdehydeMiceMice, TransgenicNeoplasms, Radiation-InducedRadiation, IonizingRadiation ProtectionSpace FlightWhole-Body IrradiationMalondialdehydeCDDO-EAGCR simulationIonizing radiationMultiple Ions

Identifiers

PMID31987474
PMCPMC6991460
OpenAlexW2964446146

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.