Evidence map›Paper›PMID 31987008›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020

Microglia alter the threshold of spreading depolarization and related potassium uptake in the mouse brain.

Dániel P Varga, Ákos Menyhárt, Balázs Pósfai, Eszter Császár, Nikolett Lénárt, Csaba Cserép, Barbara Orsolits, Bernadett Martinecz, Tamás Szlepák, Ferenc Bari and 2 more

Abstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. The endocannabinoid system and breathing.Frontiers in neuroscience · 2023
    Review
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  15. Microglia, the brain's double agent.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  16. Article
  17. The Safeguarding Microglia: Central Role for P2YFrontiers in pharmacology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dániel P VargaDepartment of Medical Physics and Informatics, University of Szeged, Szeged, Hungary.
Ákos MenyhártDepartment of Medical Physics and Informatics, University of Szeged, Szeged, Hungary.
Balázs PósfaiLaboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.ORCID 0000-0003-1035-565X
Eszter CsászárLaboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
Nikolett LénártLaboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
Csaba CserépLaboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.ORCID 0000-0001-5513-2471
Barbara OrsolitsLaboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
Bernadett MartineczLaboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
Tamás SzlepákLaboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
Ferenc BariDepartment of Medical Physics and Informatics, University of Szeged, Szeged, Hungary.
Eszter FarkasDepartment of Medical Physics and Informatics, University of Szeged, Szeged, Hungary.
Ádám DénesLaboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selective elimination of microglia from the brain was shown to dysregulate neuronal Ca

Indexed as

AnimalsBrain IschemiaDisease Models, AnimalMaleMiceMicrogliaPotassiumPotassiumextracellular potassium clearanceinflammationMicrogliaP2Y12 receptorspreading depolarization

Identifiers

PMID31987008
PMCPMC7687034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.