Evidence map›Paper›PMID 31986571›Full record

ArticleThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi2020

Clinical Features and Outcomes of Tuberculosis in Inflammatory Bowel Disease Patients Treated with Anti-tumor Necrosis Factor Therapy.

Jihye Kim, Jong Pil Im, Jae-Joon Yim, Chang Kyun Lee, Dong Il Park, Chang Soo Eun, Sung-Ae Jung, Jeong Eun Shin, Kang-Moon Lee, Jae Hee Cheon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Jihye KimDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Jong Pil ImDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.ORCID 0000-0003-1584-0160
Jae-Joon YimDepartment of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Korea.
Chang Kyun LeeDepartment of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
Dong Il ParkDepartment of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
Chang Soo EunDepartment of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
Sung-Ae JungDepartment of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
Jeong Eun ShinDepartment of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
Kang-Moon LeeDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jae Hee CheonDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Seoul National University · KRCatholic University of Korea · KRDankook University · KREwha Womans University · KRHanyang University Guri Hospital · KRKyung Hee University · KRSungkyunkwan University · KRYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: Anti-tumor necrosis factor (TNF) therapy is used widely for the treatment of inflammatory bowel disease (IBD). In the present study, the characteristics and outcomes of tuberculosis (TB) in IBD patients treated with anti-TNF therapy were compared with those of non-IBD TB patients. Methods: Twenty-five IBD patients who initially developed TB during anti-TNF therapy were enrolled in this study. Seventy-five ageand gender-matched non-IBD TB patients were selected as controls in a 1:3 ratio. Results: The proportion of non-respiratory symptoms was higher in the IBD patients than in the non-IBD patients (12 [48.0%] in the IBD patients vs. 15 [20.0%] in the non-IBD patients; p=0.009). Eight (32.0%) IBD patients and 19 (25.3%) non-IBD patients had extra- pulmonary lesions (p=0.516). The frequency of positive smear results for acid-fast bacilli (AFB) was significantly higher in the non-IBD patients than in the IBD patients (three [12.0%] IBD patients vs. 27 [36.0%] non-IBD patients; p=0.023). Active TB was cured in 24 (96.0%) patients in the IBD group and in 70 (93.3%) patients in the non-IBD group (p=0.409). The TB-related mortality rates were 4.0% and 1.3% in the IBD patients and non-IBD patients, respectively (p=0.439). Conclusions: The rate of extrapulmonary involvement, side effects of anti-TB medications, and clinical outcomes did not differ between the IBD patients who initially developed TB during anti-TNF therapy and non-IBD patients with TB. On the other hand, the IBD patients had a lower rate of AFB smear positivity and a higher proportion of non-respiratory symptoms.

Indexed as

AdolescentAdultAgedCase-Control StudiesGastrointestinal AgentsHumansInflammatory Bowel DiseasesInfliximabMaleMiddle AgedPrognosisRetrospective StudiesTuberculosisTumor Necrosis Factor-alphaYoung AdultGastrointestinal AgentsInfliximabTumor Necrosis Factor-alphaInflammatory bowel diseasesTuberculosisTumor necrosis factor inhibitors

Identifiers

PMID31986571
PMCPMC12285826
OpenAlexW3005348673

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.