ArticleJournal of neural engineering2020
Toward guiding principles for the design of biologically-integrated electrodes for the central nervous system.
Article in Journal of neural engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed.
- A comparative study assessing neural recording quality and inflammatory tissue response between stiff and flexible microelectrode arrays.Biomaterials · 2026Article
- Antimicrobial coated intracortical probes reduce invading microbe abundance and subsequent neuroinflammation.Biomaterials · 2026Article
- A method for efficient, rapid, and minimally invasive implantation of individual non-functional motes with penetrating subcellular-diameter carbon fiber electrodes into rat cortex.Frontiers in neuroscience · 2026Article
- Spatial transcriptomics on an expanded dataset at the brain-electrode interface: exploration of variability and identification of novel biomarkers.Frontiers in neuroscience · 2026Article
- 3D-Printing of Electroconductive MXene-Based Micro-Meshes in a Biomimetic Hyaluronic Acid-Based Scaffold Directs and Enhances Electrical Stimulation for Neural Repair Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- DiffCoRank: a comprehensive framework for discovering hub genes and differential gene co-expression in brain implant-associated tissue responses.BMC bioinformatics · 2025Article
- Biological and Mechanical Limitations for Chronic Fast-Scan Cyclic Voltammetry Sensor Design.Advanced materials technologies · 2025Article
- In vivo microelectrode arrays for neuroscience.Nature reviews. Methods primers · 2025Article
- Potential of Photoelectric Stimulation with Ultrasmall Carbon Electrode on Neural Tissue: New Directions in Neurostimulation Technology Development.Advanced functional materials · 2024Article
- Spatial transcriptomics at the brain-electrode interface in rat motor cortex and the relationship to recording quality.Journal of neural engineering · 2024Article
- Evaluation of In Vitro Serotonin-Induced Electrochemical Fouling Performance of Boron Doped Diamond Microelectrode Using Fast-Scan Cyclic Voltammetry.Biosensors · 2024Article
- Double Electrode Experiments Reveal the Processes Occurring at PEDOT-Coated Neural Electrode Arrays.ACS applied materials & interfaces · 2024Article
- Structural, Functional, and Genetic Changes Surrounding Electrodes Implanted in the Brain.Accounts of chemical research · 2024Article
- Structural and functional changes of deep layer pyramidal neurons surrounding microelectrode arrays implanted in rat motor cortex.Acta biomaterialia · 2023Article
- Post-explant profiling of subcellular-scale carbon fiber intracortical electrodes and surrounding neurons enables modeling of recorded electrophysiology.Journal of neural engineering · 2023Article
- Utah array characterization and histological analysis of a multi-year implant in non-human primate motor and sensory cortices.Journal of neural engineering · 2023Article
- Spatiotemporal patterns of gene expression around implanted silicon electrode arrays.Journal of neural engineering · 2021Article
- Brain-Computer Interfaces in Neurorecovery and Neurorehabilitation.Seminars in neurology · 2021Article
- Next-Generation Diamond Electrodes for Neurochemical Sensing: Challenges and Opportunities.Micromachines · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Innovation in electrode design has produced a myriad of new and creative strategies for interfacing the nervous system with softer, less invasive, more broadly distributed sites with high spatial resolution. However, despite rapid growth in the use of implanted electrode arrays in research and clinical applications, there are no broadly accepted guiding principles for the design of biocompatible chronic recording interfaces in the central nervous system (CNS). Studies suggest that the architecture and flexibility of devices play important roles in determining effective tissue integration: device feature dimensions (varying from 'sub'- to 'supra'-cellular scales, <10 µm to >100 µm), Young's modulus, and bending modulus have all been identified as key features of design. However, critical knowledge gaps remain in the field with respect to the underlying motivation for these designs: (1) a systematic study of the relationship between device design features (materials, architecture, flexibility), biointegration, and signal quality needs to be performed, including controls for interaction effects between design features, (2) benchmarks for success need to be determined (biological integration, recording performance, longevity, stability), and (3) user results, particularly those that champion a specific design or electrode modification, need to be replicated across laboratories. Finally, the ancillary effects of factors such as tethering, site impedance and insertion method need to be considered. Here, we briefly review observations to-date of device design effects on tissue integration and performance, and then highlight the need for comprehensive and systematic testing of these effects moving forward.
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