ArticlePloS one2020
The relationship between stress and vitiligo: Evaluating perceived stress and electronic medical record data.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Global clinicoepidemiological pattern of childhood vitiligo: a systematic review and meta-analysis.BMJ paediatrics open · 2023Pooled it
- The humanistic burden of vitiligo: a systematic literature review of quality-of-life outcomes.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Pooled it
- Systematic Evaluation and Meta-Analysis of Randomized Controlled Trials of Fire Needle Combined Phototherapy for the Treatment of Vitiligo.BioMed research international · 2022Pooled it
- Psychosocial Effects of Vitiligo: A Systematic Literature Review.American journal of clinical dermatology · 2021Pooled it
- Balancing inflammation under stress: glucocorticoid regulation of innate immune pathways.Bioscience reports · 2026Review
- Markers of Systemic Metabolic Dysfunction in Vitiligo and Their Potential Role in Disease Pathogenesis: A Narrative Review.Health science reports · 2026Article
- Methodological strategies for mappingWorld journal of methodology · 2026Review
- Neuropeptide Y drives vitiligo progression via NPYR-mediated NF-κB activation: a novel therapeutic target.Scientific reports · 2026Article
- Development and validation of an Arabic vitiligo impact patient scale short form version.JAAD international · 2026Article
- ORIGINAL RESEARCH.Discover mental health · 2026Article
- Prevalence and Association of Autoimmune Comorbidities Among Adults with Vitiligo: A Systematic Literature Review and Meta-analysis of USA-Based Studies.Dermatology and therapy · 2025Review
- A Vitiligo-like Cutaneous Reaction Induced by Ribociclib in Advanced Breast Cancer: An Unusual Case Report from Colombia.Diseases (Basel, Switzerland) · 2025Article
- Beyond skin deep: exploring the complex molecular mechanisms and holistic management strategies of vitiligo.Archives of dermatological research · 2025Review
- Knowledge, attitude, and practice toward vitiligo among vitiligo patients: a mediation analysis.Scientific reports · 2025Article
- Enhancing Repigmentation in Vitiligo: A Comparative Clinical Trial of Microneedling with Topical 5-Fluorouracil, Fluocinolone, and Microneedling Alone.World journal of plastic surgery · 2025Article
- Local sympathetic nerve depletion does not alter vitiligo progression in a mouse model.Frontiers in medicine · 2025Article
- Stressful life events in electronic health records: a scoping review.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Healthcare Resource Use and Costs Among Individuals with Vitiligo and Psychosocial Comorbidities: Retrospective Analysis of an Insured US Population.ClinicoEconomics and outcomes research : CEOR · 2024Article
- The Sequelae and Moderators of Influence of Dandruff on Mental Health Among Mainland Chinese Adults.Clinical, cosmetic and investigational dermatology · 2024Article
- Stressful life events in electronic health records: a scoping review.Research square · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Vitiligo is a T-cell mediated skin disorder characterized by progressive loss of skin color. In individuals genetically predisposed to the disease, various triggers contribute to the initiation of vitiligo. Precipitating factors can stress the skin, leading to T-cell activation and recruitment. Though hereditary factors are implicated in the pathogenesis of vitiligo, it is unknown whether precipitating, stressful events play a role in vitiligo. To understand this, we utilized a validated perceived stress scale (PSS) to measure this parameter in vitiligo patients compared to persons without vitiligo. Additionally, we probed a clinical database, using a knowledge linking software called ROCKET, to gauge stress-related conditions in the vitiligo patient population. From a pool of patients in an existing database, a hundred individuals with vitiligo and twenty-five age- and sex-matched comparison group of individuals without vitiligo completed an online survey to quantify their levels of perceived stress. In parallel, patients described specifics of their disease condition, including the affected body sites, the extent, duration and activity of their vitiligo. Perceived stress was significantly higher among vitiligo individuals compared to those without vitiligo. ROCKET analyses suggested signs of metabolic-related disease (i.e., 'stress') preceding vitiligo development. No correlation was found between perceived stress and the stage or the extent of disease, suggesting that elevated stress may not be a consequence of pigment loss alone. The data provide further support for stress as a precipitating factor in vitiligo development.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.