Evidence map›Paper›PMID 31986149›Full record

ArticlePloS one2020

Pseudolesion in the right parafissural liver parenchyma on CT: The base is found in embryology and collagen content.

Willemijn M Klein, Lianne J P Sonnemans, Sabine Franckenberg, Barbara Fliss, Dominic Gascho, Mathias Prokop, Wouter H Lamers, Jill P J M Hikspoors, Michael J Thali, Patricia M Flach

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Willemijn M KleinDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0003-4309-533X
Lianne J P SonnemansDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0001-8025-9669
Sabine FranckenbergDepartment of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zürich, Zürich, Switzerland.
Barbara FlissDepartment of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zürich, Zürich, Switzerland.
Dominic GaschoDepartment of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zürich, Zürich, Switzerland.
Mathias ProkopDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Wouter H LamersDepartment of Anatomy and Embryology, Maastricht University, Maastricht, the Netherlands.
Jill P J M HikspoorsDepartment of Anatomy and Embryology, Maastricht University, Maastricht, the Netherlands.
Michael J ThaliDepartment of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zürich, Zürich, Switzerland.
Patricia M FlachDepartment of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zürich, Zürich, Switzerland.
University of Zurich · CHRadboud University Nijmegen · NLMaastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComputed tomography (CT) images of livers may show a hypo-attenuated structure alongside the falciform ligament, which can be a focal fatty pseudolesion and can mimic a malignancy. The preferred location is on the right parafissural site, ventral in segment IVa/b. The etiology is not clear, nor is it known how the histology of this location develops. These are evaluated in this study.

methods40 adult cadavers with autopsy and / or postmortem CT in a university hospital and a forensic center were included. Liver biopsies were taken at the left side of the falciform ligament as control, and at the right side as the possible precursor of a pseudolesion; these were examined for collagen and fat content. Cadavers with steatotic (>5% fat) or fibrotic (>2% collagen) control samples were excluded.

resultsSignificantly more collagen was present in the right parafissural liver parenchyma: median 0.68% (IQR: 0.32-1.17%), compared to the left side 0.48% (IQR: 0.21-0.75%) (p 0.008), with equal fat content and CT attenuation values. The etiophysiology goes back to the demise of the umbilical venes in the early embryonic and neonatal period.

conclusionsThe right parafissural area contains more collagen and an equal amount of fat compared to the control left side. This supports the hypothesis of delayed, 'third' inflow: the postnatal change in blood supply from umbilical to portal leaves the downstream parafissural area hypoperfused leading to hypoxia which in turn results in collagen accumulation and the persistence of paraumbilical veins of Sappey.

Indexed as

Diagnosis, DifferentialAdultAutopsyBiopsyCadaverCollagenFatty LiverFemaleHumansLigamentsLiverLiver NeoplasmsMaleMesenteryMiddle AgedPortal VeinCollagen

Identifiers

PMID31986149
PMCPMC6984698
OpenAlexW3003208452

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.