Evidence map›Paper›PMID 31986125›Full record

ArticleAging2020

TP53/miR-34a-associated signaling targets

Shaw M Akula, Peter P Ruvolo, James A McCubrey

Open access · greenAbstract read
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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  18. Down-Regulation ofFrontiers in oncology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Shaw M AkulaDepartment of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834,USA.
Peter P RuvoloDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
James A McCubreyDepartment of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834,USA.
East Carolina University · USThe University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Functional Proteomics by Reverse Phase Protein Array in CancerR50CA221675 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LU, YILING · 2017 to 2021
$726k
Tissue Lysate Arrays for Molecular Screening (RMI)R03NS050840 · NINDS · UNIVERSITY OF TEXAS MD ANDERSON CAN CTR · PI LU, YILING · 2004 to 2004
$76k
NCI NIH HHS P30 CA016672NCI NIH HHS R50 CA221675NINDS NIH HHS R03 NS050840
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a disease of aging. The

Indexed as

Antineoplastic AgentsApoptosisBerberineCell Line, TumorCell MovementCell ProliferationCell SurvivalGene Expression Regulation, NeoplasticHumansMicroRNAsPancreatic NeoplasmsPlasminogen Activator Inhibitor 1Signal TransductionTumor Suppressor Protein p53Antineoplastic AgentsBerberineMicroRNAsMIRN34 microRNA, humanPlasminogen Activator Inhibitor 1SERPINE1 protein, humanTP53 protein, humanTumor Suppressor Protein p53AgingcancermiR-34aPDACSERPINE1TP53

Identifiers

PMID31986125
PMCPMC7041729
OpenAlexW3003612751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.