Evidence map›Paper›PMID 31985460›Full record

Observational studyJournal of Alzheimer's disease : JAD2020

Costs and Resource Use Associated with Community-Dwelling Patients with Alzheimer's Disease in Japan: Baseline Results from the Prospective Observational GERAS-J Study.

Miharu Nakanishi, Ataru Igarashi, Kaname Ueda, Alan J M Brnabic, Tamas Treuer, Masayo Sato, Kristin Kahle-Wrobleski, Kenichi Meguro, Masahito Yamada, Masaru Mimura and 1 more

Open access · bronzeAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 3 countries.

Miharu NakanishiMental Health and Nursing Research Team, Mental Health Promotion Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Ataru IgarashiDepartment of Health Economics and Outcomes Research, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan, and Yokohama City University, Yokohama, Japan.
Kaname UedaEli Lilly Japan K.K, Kobe, Japan.
Alan J M BrnabicEli Lilly Australia Pty. Limited, West Ryde, Australia.
Tamas TreuerEli Lilly and Company, Budapest, Hungary, EU.
Masayo SatoEli Lilly Japan K.K, Kobe, Japan.
Kristin Kahle-WrobleskiEli Lilly and Company, Indianapolis, IN, USA.
Kenichi MeguroGeriatric Behavioral Neurology Project, New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai, Japan, Division of Nuclear Medicine, Cyclotron Radioisotope Center (CYRIC), Tohoku University, Sendai, Japan, and The Osaki-Tajiri SKIP Center, Osaki, Japan.
Masahito YamadaDepartment of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Masaru MimuraDepartment of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan.
Heii AraiALZCLINIC TOKYO, Tokyo, Japan.
Eli Lilly (Japan) · JPELI-HU Research and Development Non-Profit · HUEli Lilly (United States) · USKanazawa University · JPKeio University · JPThe University of Tokyo · JPTohoku University · JPTokyo Metropolitan Institute of Medical Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs the Japanese population ages, caring for people with Alzheimer's disease (AD) dementia is becoming a major socioeconomic issue.

objectiveTo determine the contribution of patient and caregiver costs to total societal costs associated with AD dementia.

methodsBaseline data was used from the longitudinal, observational GERAS-J study. Using the Mini-Mental State Examination (MMSE) score, patients routinely visiting memory clinics were stratified into three groups based on AD severity. Health care resource utilizationwas recorded using the Resource Utilization in Dementia questionnaire. Total monthly societal costs were estimated using Japan-specific unit costs of services and products (patient direct health care use, patient social care use, and informal caregiving time). Uncertainty around mean costs was estimated using bootstrapping methods.

resultsOverall, 553 community-dwelling patients withADdementia (28.3% mild[MMSE21-26], 37.8% moderate[MMSE 15-20], and 34.0% moderately severe/severe [MMSE < 14]) and their caregivers were enrolled. Patient characteristics were: mean age 80.3 years, 72.7% female, and 13.6% living alone. Caregiver characteristics were: mean age 62.1 years, 70.7% female, 78.8% living with patient, 49.0% child of patient, and 39.2% sole caregiver. Total monthly societal costs of AD dementia (Japanese yen) were: 158,454 (mild), 211,301 (moderate), and 294,224 (moderately severe/severe). Informal caregiving costs comprised over 50% of total costs.

conclusionBaseline results of GERAS-J showed that total monthly societal costs associated with AD dementia increased with AD severity. Caregiver-related costs were the largest cost component. Interventions are needed to decrease informal costs and decrease caregiver burden.

Indexed as

Activities of Daily LivingAgedAged, 80 and overAlzheimer DiseaseCaregiversCosts and Cost AnalysisFemaleHealth Care CostsHumansIndependent LivingJapanLongitudinal StudiesMaleMental Status and Dementia TestsMiddle AgedProspective StudiesAlzheimer’s diseasecost and cost analysisJapanobservational study

Identifiers

PMID31985460
PMCPMC7175940
OpenAlexW3001685230

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.