ArticleeLife2020
celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- The Function and Regulation of celsr1a in Skeletal Age-associated Homeostasis and Repair in Zebrafish.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Skeletal Muscle Aging: Lessons From Teleosts.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Review
- Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish.Communications biology · 2024Article
- Systematic Characterization of the Disruption of Intestine during Liver Tumor Progression in theCells · 2022Article
- Aging Activates the Immune System and Alters the Regenerative Capacity in the Zebrafish Heart.Cells · 2022Article
- The RNA helicase Ddx52 functions as a growth switch in juvenile zebrafish.Development (Cambridge, England) · 2021Article
- Postembryonic screen for mutations affecting spine development in zebrafish.Developmental biology · 2021Article
- Zebrafish models of sarcopenia.Disease models & mechanisms · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The use of genetics has been invaluable in defining the complex mechanisms of aging and longevity. Zebrafish, while a prominent model for vertebrate development, have not been used systematically to address questions of how and why we age. In a mutagenesis screen focusing on late developmental phenotypes, we identified a new mutant that displays aging phenotypes at young adult stages. We find that the phenotypes are due to loss-of-function in the non-classical cadherin
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.