Evidence map›Paper›PMID 31985300›Full record

ReviewExpert opinion on investigational drugs2020

Investigational plasma kallikrein inhibitors for the treatment of diabetic macular edema: an expert assessment.

Ashay D Bhatwadekar, Viral S Kansara, Thomas A Ciulla

Open access · greenAbstract readReview
In one paragraph

Review in Expert opinion on investigational drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Diabetic retinal disease.Nature reviews. Disease primers · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Kinins and Their Receptors in Infectious Diseases.Pharmaceuticals (Basel, Switzerland) · 2020
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Ashay D BhatwadekarDepartment of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University, Indianapolis, IN, USA.
Viral S KansaraClearside Biomedical, Inc., Alpharetta, GA, USA.
Thomas A CiullaDepartment of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University, Indianapolis, IN, USA.
Clearside Biomedical (United States) · USHypertension Institute · USIndiana University – Purdue University Indianapolis · US

Funding

Retinal dysfunction in Alzheimer's disease mouse modelsR01EY027779 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI BHATWADEKAR, ASHAY D · 2017 to 2021
$2.4M
NEI NIH HHS R01 EY027779
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsDiabetic RetinopathyDrug DevelopmentDrugs, InvestigationalHumansMacular EdemaPlasma KallikreinDrugs, InvestigationalPlasma Kallikreindiabetic macular edemaDiabetic retinopathyplasma kallikreinvascular endothelial growth factorvascular permeability

Identifiers

PMID31985300
PMCPMC7265898
OpenAlexW3003692319

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.