Evidence map›Paper›PMID 31985216›Full record

ArticleJournal of the American Chemical Society2020

Nanopore Sequencing of an Expanded Genetic Alphabet Reveals High-Fidelity Replication of a Predominantly Hydrophobic Unnatural Base Pair.

Michael P Ledbetter, Jonathan M Craig, Rebekah J Karadeema, Matthew T Noakes, Hwanhee C Kim, Sarah J Abell, Jesse R Huang, Brooke A Anderson, Ramanarayanan Krishnamurthy, Jens H Gundlach and 1 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Reverse transcription as key step in RNARSC chemical biology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Real-time label-free detection of dynamic aptamer-small molecule interactions using a nanopore nucleic acid conformational sensor.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael P LedbetterDepartment of Chemistry , The Scripps Research Institute , La Jolla , California 92037 , United States.
Jonathan M CraigDepartment of Physics , University of Washington , Seattle , Washington 98195 , United States.
Rebekah J KaradeemaDepartment of Chemistry , The Scripps Research Institute , La Jolla , California 92037 , United States.ORCID 0000-0001-6634-8411
Matthew T NoakesDepartment of Physics , University of Washington , Seattle , Washington 98195 , United States.
Hwanhee C KimDepartment of Physics , University of Washington , Seattle , Washington 98195 , United States.
Sarah J AbellDepartment of Physics , University of Washington , Seattle , Washington 98195 , United States.
Jesse R HuangDepartment of Physics , University of Washington , Seattle , Washington 98195 , United States.
Brooke A AndersonDepartment of Chemistry , The Scripps Research Institute , La Jolla , California 92037 , United States.
Ramanarayanan KrishnamurthyDepartment of Chemistry , The Scripps Research Institute , La Jolla , California 92037 , United States.ORCID 0000-0001-5238-610X
Jens H GundlachDepartment of Physics , University of Washington , Seattle , Washington 98195 , United States.
Floyd E RomesbergDepartment of Chemistry , The Scripps Research Institute , La Jolla , California 92037 , United States.ORCID 0000-0001-6317-1315

Funding

Nanopore sequencing of DNA with MspAR01HG005115 · NHGRI · UNIVERSITY OF WASHINGTON · PI GUNDLACH, JENS, LASZLO, ANDREW · 2009 to 2024
$14.0M
A semi-synthetic organism that stores and retrieves increased genetic informationR35GM118178 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI ROMESBERG, FLOYD E. · 2016 to 2018
$2.1M
Engineering translation machinery for a semi-synthetic organismF31GM128376 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI KARADEEMA, REBEKAH J · 2018 to 2020
$96k
NHGRI NIH HHS R01 HG005115NIGMS NIH HHS F31 GM128376NIGMS NIH HHS R35 GM118178
6 · The paper itself

Abstract

Unnatural base pairs (UBPs) have been developed and used for a variety of

Indexed as

Base PairingGenetic CodeNanoporesHydrophobic and Hydrophilic Interactions

Identifiers

PMID31985216
PMCPMC7263177

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.