ArticleBrain and behavior2020
Uric acid is associated with cognitive impairment in the elderly patients receiving maintenance hemodialysis-A two-center study.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Cognitive Impairment in End Stage Renal Disease Patients Undergoing Hemodialysis: Markers and Risk Factors.International journal of environmental research and public health · 2022Pooled it
- Effect of Interactive Dynamic Scalp Acupuncture on Post-Stroke Cognitive Function, Depression, and Anxiety: A Multicenter, Randomized, Controlled Trial.Chinese journal of integrative medicine · 2022Trial
- Serum ICAM-1 as a Predictor of Prognosis in Patients with Acute Ischemic Stroke.BioMed research international · 2021Trial
- Association between fasting serum uric acid levels and Alzheimer's disease in nursing home residents: a cross-sectional study.Frontiers in nutrition · 2026Article
- Association of anemia and cognitive impairment in patients undergoing maintenance hemodialysis: a cross-sectional study.BMC nephrology · 2025Article
- Non-Invasive Screening for Early Cognitive Impairment in Elderly Hyperuricaemic Men Using Transcranial Colour-Coded Duplex Sonography.Diagnostics (Basel, Switzerland) · 2025Article
- Cognitive impairment and blood biomarkers of renal dysfunction in high-risk Nigerian population, with special attention to women and diabetes.BMC neurology · 2025Article
- Article
- Association between kidney measurements and cognitive performance in patients with ischemic stroke.PloS one · 2023Article
- Effects of 24-Form Tai Chi on Cardio-Pulmonary Functions, Exercise Performances, and Cognitive Functions of the Aged.Iranian journal of public health · 2022Article
- Traditional Chinese medicine promotes the control and treatment of dementia.Frontiers in pharmacology · 2022Review
- Cognitive Function and Vitamin D Status in the Chinese Hemodialysis Patients.Computational and mathematical methods in medicine · 2022Article
- The Influence of Serum Uric Acid on the Brain and Cognitive Dysfunction.Frontiers in psychiatry · 2022Review
- The Prognostic Value of Serum Uric Acid in Hospitalized Patients with Acute Cerebral Infarction.Disease markers · 2021Article
- Association Between Serum Uric Acid Levels and Cognitive Function in Patients with Ischemic Stroke and Transient Ischemic Attack (TIA): A 3-Month Follow-Up Study.Neuropsychiatric disease and treatment · 2021Article
- IL-33 as a Novel Serum Prognostic Marker of Intracerebral Hemorrhage.Oxidative medicine and cellular longevity · 2021Article
- The Influence of Serum Uric Acid Level on Alzheimer's Disease: A Narrative Review.BioMed research international · 2021Review
- Serum Neuropeptide Y: A Potential Prognostic Marker of Intracerebral Hemorrhage.Disease markers · 2021Article
- Decreased Serum NCAM Levels Associated with Cognitive Impairment in Vascular Dementia.Disease markers · 2021Article
- Serum Irisin as a Potential Biomarker for Cognitive Decline in Vascular Dementia.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundElevated serum uric acid (SUA) has been associated with vascular cognitive impairment (CI) in the elderly. However, its relationship with cognitive function in the elderly patients receiving maintenance hemodialysis (MHD) has not yet been elucidated.
objectiveThe cognitive impairment is prevalent in MHD patients. Various insults may contribute to cognitive impairment in patients with MHD. The aim of this study was to investigate the relationship between SUA and CI in the elderly patients receiving MHD.
methodsA total of 180 elderly MHD subjects from two hospitals were enrolled in our study. Cognitive function domains were evaluated by MMSE at the beginning of the trial. Demographic and clinical characteristics were collected and recorded.
resultsThe subjects were stratified into quartiles according to SUA level. Demographic and clinical characteristics such as age, gender, smoking habit, education year, blood pressure (BP), hemoglobin, albumin, blood glucose (BG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), blood urea nitrogen (BUN), and serum creatinine (Scr) did not differ dramatically among groups (p > .05). The Q1 group showed the highest MMSE scores, and the Q4 group showed the lowest MMSE sores (p < .05). There was a negative correlation between SUA and MMSE scores (r = -.307, p = .014), and this correlation was independent of demographic and clinical characteristics.
conclusionsElevated SUA maybe contributes to CI in the elderly MHD patients. SUA level is independent risk for the CI in the elderly MHD patients.
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