Evidence map›Paper›PMID 31984768›Full record

ArticleChronic respiratory disease

Hospitalization rates among patients with cystic fibrosis using pancreatic enzyme replacement therapy.

Bruce C Trapnell, Su Chen, Rupal Khurmi, Amit Bodhani, Mudra Kapoor, Mark Haupt

Open access · goldAbstract read
In one paragraph

Article in Chronic respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Health care costs in a randomized trial of antimicrobial duration among cystic fibrosis patients with pulmonary exacerbations.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2022
    Trial
  2. Trial
  3. Article
  4. Review
  5. Disease burden in people with cystic fibrosis heterozygous for F508del and a minimal function mutation.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2022
    Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Bruce C TrapnellDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Su ChenAbbVie Inc., North Chicago, IL, USA.
Rupal KhurmiAbbVie Inc., North Chicago, IL, USA.
Amit BodhaniAbbVie Inc., North Chicago, IL, USA.
Mudra KapoorAbbVie Inc., North Chicago, IL, USA.
Mark HauptAbbVie Inc., North Chicago, IL, USA.
AbbVie (United States) · USCincinnati Children's Hospital Medical Center · US

Funding

Role of GM-CSF in Myeloid Cell Function and Innate ImmunityR01HL085453 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TRAPNELL, BRUCE C · 2007 to 2023
$6.5M
NHLBI NIH HHS R01 HL085453
6 · The paper itself

Abstract

We investigated the relationship between self-reported adherence to pancreatic enzyme replacement therapy (PERT), nutritional status, and all-cause hospitalization in cystic fibrosis (CF) patients with a record of PERT use. Association of self-reported annual PERT use rate (adherence) with annual hospital admission rate (HAR) and annual total hospital nights (THNs) were analyzed for 5301 children (2000-2012) and 13,989 adults (2000-2013) from the CF Foundation Patient Registry. Multivariate linear regression was used to determine the association of HAR and THN with mean annual PERT use rate, cumulative PERT use rate, mean body mass index (BMI) (adult) or BMI percentile (pediatric), age, and sex. The median annual PERT use rate was 87% in children and 80% in adults. Statistically, higher annual PERT use, longer cumulative PERT, and higher BMI percentile (children) or BMI (adults) were significantly (

Indexed as

Body Mass IndexCystic FibrosisAdultAge FactorsChildEnzyme Replacement TherapyFemaleHospitalizationHumansMaleNutritional StatusRegistriesRetrospective StudiesSelf ReportSex FactorsTreatment Adherence and ComplianceadultExocrine pancreatic insufficiencyhospitalizationpancreatic enzyme replacement therapypediatrictreatment adherence

Identifiers

PMID31984768
PMCPMC6985972
OpenAlexW3000818032

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.