SynthesisJournal of thrombosis and haemostasis : JTH2020
Epidemiology and outcomes of clinically unsuspected venous thromboembolism in children: A systematic review.
Synthesis in Journal of thrombosis and haemostasis : JTH, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Factors Associated With Thromboembolism in Neonates: A Systematic Review and Meta-Analysis.JAMA network open · 2026Pooled it
- Incidence of neonatal venous thromboembolism: a systematic review and meta-analysis of the literature.Research and practice in thrombosis and haemostasis · 2026Pooled it
- Direct oral anticoagulants versus standard anticoagulation in children treated for acute venous thromboembolism.Pediatric research · 2023Pooled it
- Incidental pulmonary embolism in oncologic patients-a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Pooled it
- Article
- Pediatric Cardiac Arrest From Tumor-Associated Pulmonary Embolism: Diagnostic Insights From Imaging After Extracorporeal Cardiopulmonary Resuscitation.JACC. Case reports · 2026Article
- Rare pediatric multi-system thrombosis post-COVID-19: a three-year follow-up case report and narrative review on rivaroxaban for long-term management.Orphanet journal of rare diseases · 2026Review
- Therapeutic targets for venous thromboemblism: proteome-wide mendelian randomization and colocalization analyses.Thrombosis journal · 2025Article
- Pediatric pulmonary embolism: Unveiling clinical manifestations, diagnostic challenges, and outcomes in Southwest China.Pediatric discovery · 2025Article
- Pediatric venous thromboembolism: incidence and patient profile in a single Brazilian institution.Hematology, transfusion and cell therapy · 2024Article
- Assessment of the clinical and laboratory risk factors for thrombosis in neonates admitted to neonatal intensive care unit (two Egyptian tertiary centers experience).Annals of hematology · 2024Article
- Evidence-based summary of preventive care for central venous access device-related thrombosis in hospitalized children.BMC nursing · 2024Article
- Thromboembolism in Children.Indian journal of pediatrics · 2024Article
- Urokinase prophylactic anticoagulation in children with nephrotic syndrome: a multicenter retrospective cohort study.BMC nephrology · 2024Article
- Review
- Characteristics of Deep Venous Thrombosis in Isolated Lower Extremity Fractures and Unsolved Problems in Guidelines: A Review of Recent Literature.Orthopaedic surgery · 2022Review
- Recommendations for standardized definitions, clinical assessment, and future research in pediatric clinically unsuspected venous thromboembolism: Communication from the ISTH SSC subcommittee on pediatric and neonatal thrombosis and hemostasis.Journal of thrombosis and haemostasis : JTH · 2022Article
- Challenges in Management of VTE in Children With Cancer: Risk Factors and Treatment Options.Frontiers in pediatrics · 2022Review
- International pediatric thrombosis network to advance pediatric thrombosis research: Communication from the ISTH SSC subcommittee on pediatric and neonatal thrombosis and hemostasis.Journal of thrombosis and haemostasis : JTH · 2021Article
- Safety and efficacy of anticoagulant therapy in pediatric catheter-related venous thrombosis (EINSTEIN-Jr CVC-VTE).Blood advances · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 5 countries.
Funding
Abstract
backgroundClinically unsuspected venous thromboembolic events (uVTE) detected during routine imaging pose a management challenge due to limited knowledge about their clinical significance. Unsuspected VTE are often referred as "asymptomatic," "incidental," or "clinically silent/occult" VTE.
objectiveTo understand the epidemiology, management, and outcomes of uVTE in children.
methodsA systematic review was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The search criteria included controlled vocabulary and keywords for VTE, incidental findings, and children (ages ≤ 21 years).
resultsAmong 10 875 articles, 51 studies (8354 children with 758 uVTE) were selected. The studies were heterogeneous, I
conclusionClinically uVTE were predominantly diagnosed with CVL and their outcomes were generally favorable implying limited benefit of routine surveillance and thromboprophylaxis. Prospective research is needed to clarify the optimal management of iVTE.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.