ReviewJournal of biomedical materials research. Part B, Applied biomaterials2020
Engineering a collagen matrix for cell-instructive regenerative angiogenesis.
Review in Journal of biomedical materials research. Part B, Applied biomaterials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
- Fish Collagen Hydrolysates in Wound Healing: A Patent Review.ACS pharmacology & translational science · 2026Review
- The Digestive System of the Greater Weever (International journal of molecular sciences · 2026Article
- From Nature to Innovation: Exploring Natural Biopolymers in 3D Bioprinting for Bone Regeneration.ACS omega · 2026Article
- Synergistic Combination of Additive One- and Two-Photon Polymerization Printing Methods to Fabricate 3D Microstructured Perfusable Angiogenesis-on-a-Chip Systems.Engineering in life sciences · 2026Article
- An animal component-free bioprocess for synthesizing 3D human matrix scaffolds using mesenchymal stromal cells.Frontiers in cell and developmental biology · 2026Article
- Quality Control and Regulatory Scientific Research on Collagen-Based Medical Devices.Cell proliferation · 2026Article
- Photoprotection of a novel resveratrol analogue: insights from 2D, 3D, and endothelialized bioprinted human skin models.Frontiers in pharmacology · 2026Article
- Microenvironment-based immunotherapy in oral cancer: a comprehensive review.Medical oncology (Northwood, London, England) · 2025Review
- Development and Characterization of PEGylated Poly D,L-Lactic Acid Nanoparticles for Skin Rejuvenation.Nanomaterials (Basel, Switzerland) · 2025Article
- Plant-Derived B-CGT Hydrogel Accelerates Diabetic Wound Healing Through Multitarget Modulation of Inflammation, Angiogenesis, and Tissue Remodeling.Gels (Basel, Switzerland) · 2025Article
- Proteomic Analysis of Retinas in a Rat Model of High-Fat Diet-Induced Type 2 Diabetes: Implications of Interventional Targets for Nonproliferative Diabetic Retinopathy.Drug design, development and therapy · 2025Article
- Various Hydrogel Types as a Potential In Vitro Angiogenesis Model.Gels (Basel, Switzerland) · 2024Article
- Natural biopolymer-based hydrogels: an advanced material for diabetic wound healing.Diabetology international · 2024Review
- Review
- Glycosaminoglycans Modulate the Angiogenic Ability of Type I Collagen-Based Scaffolds by Acting on Vascular Network Remodeling and Maturation.Bioengineering (Basel, Switzerland) · 2024Article
- The construction of a microenvironment with the vascular network by co-culturing fibroblasts and endothelial cells.Regenerative therapy · 2024Article
- Biofabrication of engineered blood vessels for biomedical applications.Science and technology of advanced materials · 2024Review
- Tissue engineering applications of recombinant human collagen: a review of recent progress.Frontiers in bioengineering and biotechnology · 2024Review
- Changes of collagen content in lung tissues of plateau yak and its mechanism of adaptation to hypoxia.PeerJ · 2024Article
- Deciphering Collagen Phenotype Dynamics Regulators: Insights from In-Silico Analysis.Journal of bioinformatics and systems biology : Open access · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Engineering an angiogenic material for regenerative medicine requires knowledge of native extracellular matrix remodeling by cellular processes in angiogenesis. Vascularization remains a key challenge in the field of tissue engineering, one that can be mitigated by developing platforms conducive to guiding dynamic cell-matrix interactions required for new vessel formation. In this review, we highlight nuanced processes of angiogenesis and demonstrate how materials engineering is being used to interface with dynamic type I collagen remodeling, Notch and VEGF signaling, cell migration, and tissue morphogenesis. Because α1(I)-collagen is secreted by endothelial tip cells during sprouting angiogenesis and required for migration, collagen is a very useful natural biomaterial and its angiogenic modifications are described. The balance between collagen types I and IV via secretion and degradation is tightly controlled by proteinases and other cell types that are capable of internalizing collagen to maintain tissue integrity. Thus, we provide examples in skin and cardiac tissue engineering of collagen tailoring in diverse cellular microenvironments for tissue regeneration. As our understanding of how to drive collagen remodeling and cellular phenotype through angiogenic pathways grows, our capabilities to model and manipulate material systems must continue to expand to develop novel applications for wound healing, angiogenic therapy, and regenerative medicine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.