ReviewAngewandte Chemie (International ed. in English)2020
Transition Metal-Mediated C-C Single Bond Cleavage: Making the Cut in Total Synthesis.
Review in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 139 citations in OpenAlex.
- Controllable site-selective C-C bond cleavage for the divergent synthesis of imidazo[1,5-RSC advances · 2025Article
- Modular esterification of unstrained carbonyls through palladium-catalyzed alkyne bridging C-C bond activation.Nature communications · 2025Article
- Synthetic Studies toward the Aphidicolin Family of Diterpenoid Natural Products.The Journal of organic chemistry · 2025Article
- C-C Bond Cleavage in the Late-Stage Biosynthesis of Huperzine Alkaloids Occurs via Enzymatic Retro-Aza-Prins Reaction.Journal of the American Chemical Society · 2025Article
- Skeletal Editing Strategies Driven by Total Synthesis.Accounts of chemical research · 2025Article
- Recent Developments in the Metal-Catalyzed Synthesis of Nitrogenous Heterocyclic Compounds.Molecules (Basel, Switzerland) · 2024Review
- Molecular complexity as a driving force for the advancement of organic synthesis.Nature reviews. Chemistry · 2024Review
- Pd-Catalyzed Ring-Opening Polymerization of Cyclobutanols through C(spMacromolecules · 2024Article
- Mechanistic Investigation, Wavelength-Dependent Reactivity, and Expanded Reactivity ofJournal of the American Chemical Society · 2024Article
- Pd-Catalyzed Formal [2 + 2]-Retrocyclization of Cyclobutanols via 2-Fold CspThe Journal of organic chemistry · 2024Article
- Mechanistic Investigation of the Rhodium-Catalyzed Transfer Hydroarylation Reaction Involving Reversible C-C Bond Activation.Journal of the American Chemical Society · 2023Article
- Carbon-carbon bond activation by Mg, Al, and Zn complexes.Chemical science · 2023Review
- Mechanism and Selectivity of Copper-Catalyzed Bromination of Distal C(spOrganometallics · 2023Article
- C(alkyl)-C(vinyl) bond cleavage enabled by Retro-Pallada-Diels-Alder reaction.Nature communications · 2023Article
- Skeletal diversification by C-C cleavage to access bicyclic frameworks from a common tricyclooctane intermediate.Chemical communications (Cambridge, England) · 2023Article
- Total Synthesis of (+)-Shearilicine.Journal of the American Chemical Society · 2023Article
- Understanding the role of ring strain in β-alkyl migration at Mg and Zn centres.Chemical science · 2023Article
- General Synthetic Approach to Diverse Taxane Cores.Journal of the American Chemical Society · 2022Article
- Development of a C-C Bond Cleavage/Vinylation/Mizoroki-Heck Cascade Reaction: Application to the Total Synthesis of 14- and 15-Hydroxypatchoulol.Journal of the American Chemical Society · 2022Article
- Reversible Homolysis of a Carbon-Carbon σ-Bond Enabled by Complexation-Induced Bond-Weakening.Journal of the American Chemical Society · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Transition-metal-mediated cleavage of C-C single bonds can enable entirely new retrosynthetic disconnections in the total synthesis of natural products. Given that C-C bond cleavage inherently alters the carbon framework of a compound, and that, under transition-metal catalysis, the generated organometallic or radical intermediate is primed for further complexity-building reactivity, C-C bond-cleavage events have the potential to drastically and rapidly remodel skeletal frameworks. The recent acceleration of the use of transition-metal-mediated cleavage of C-C single bonds in total synthesis can be ascribed to a communal recognition of this fact. In this Review, we highlight ten selected total syntheses from 2014 to 2019 that illustrate how transition-metal-mediated cleavage of C-C single bonds at either the core or the periphery of synthetic intermediates can streamline synthetic efforts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.