ArticleClinical and experimental nephrology2020
Anion gap predicts early mortality after starting hemodialysis in the elderly.
Article in Clinical and experimental nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Hypertension-Induced Renal Injury: From Pathophysiology to Therapeutic Perspectives.Biomedicines · 2026Review
- How Long Do We Have? A Retrospective Review of Palliative Extubation in the Burn Unit.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- Unveiling the hidden risks: albumin-corrected anion gap as a superior marker for cardiovascular mortality in type 2 diabetes: insights from a nationally prospective cohort study.Frontiers in endocrinology · 2024Article
- Associations of continuous anionic gap detection with the mortality in critically ill patients receiving renal replacement therapy.International urology and nephrology · 2023Article
- The relationship between albumin corrected anion gap levels and mortality in patients with asthma in the ICU.Scientific reports · 2023Article
- Delirium is independently associated with early mortality in elderly patients starting hemodialysis.Clinical and experimental nephrology · 2020Article
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9 authors at 2 institutions in 1 country.
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Abstract
backgroundSerum anion gap (AG) has recently been proven to represent a biomarker for predicting prognosis in patients with end-stage renal disease (ESRD). However, whether change in AG (ΔAG) at the time of starting hemodialysis predicts mortality after starting hemodialysis in elderly patients with ESRD remains unknown.
methodsThis retrospective cohort investigated the association between ΔAG and mortality after starting hemodialysis in the elderly. The cohort comprised patients ≥ 75 years old who started hemodialysis for ESRD at National Center for Global Health and Medicine between 2010 and 2017 and at Yokosuka Kyosai Hospital between 2007 and 2011. Patients were stratified into three groups (G1-3) based on ΔAG, calculated according to the equation: ΔAG = sodium - (chloride + bicarbonate) - 12. The primary outcome was death within 1 year of starting hemodialysis. Data were analyzed using Cox proportional hazard models with adjustments for baseline characteristics.
resultsWe enrolled 254 patients (59% male). Median ΔAG was 2.6 (G1: > 3, n = 111; G2: 0-3, n = 103; G3: < 0, n = 40). The primary outcome was observed in 43 patients. Hazard ratios (HRs) were significantly higher for G1 and G3 than for G2 (G1: HR 2.47, 95% confidence interval 1.13-5.37; G3: HR 3.86, 95% confidence interval 1.62-9.16). Adjusted HRs (aHRs) were significantly higher for G1 and G3 than for G2 (G1: aHR 3.06, 95% confidence interval 1.23-7.62; G3: aHR 3.12, 95% confidence interval 1.10-8.78).
conclusionsA J-curve phenomenon is evident between ΔAG and early mortality after starting hemodialysis in the elderly.
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