Evidence map›Paper›PMID 31984218›Full record

ArticleOptica2019

Scanless volumetric imaging by selective access multifocal multiphoton microscopy.

Yi Xue, Kalen P Berry, Josiah R Boivin, Christopher J Rowlands, Yu Takiguchi, Elly Nedivi, Peter T C So

Abstract read
In one paragraph

Article in Optica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Recover Biological Structure from Sparse-View Diffraction Images with Neural Volumetric Prior.Proceedings. IEEE International Conference on Computer Vision · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yi XueDepartment of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.
Kalen P BerryDepartment of Biology, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.
Josiah R BoivinPicower Institute, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.
Christopher J RowlandsDepartment of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.ORCID 0000-0002-8261-2371
Yu TakiguchiLaser Biomedical Research Center, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.ORCID 0000-0002-5807-9183
Elly NediviDepartment of Biology, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.
Peter T C SoDepartment of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.

Funding

Wide-Field Short-Wave Infrared (SWIR) multiphoton (MP) tissue imagingP41EB015871 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2012 to 2021
$11.3M
Research Supplement - Quantitative analyses of tumor cell extravasationU01CA202177 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KAMM, ROGER D · 2015 to 2020
$4.2M
Characterizing mechanisms of sickle cell crisis via dynamic optical assayR01HL121386 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2014 to 2016
$1.7M
Next generation high-throughput random access imaging, in vivoU01NS090438 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NEDIVI, ELLY, SO, PETER T. · 2014 to 2016
$1.4M
Novel implementation of Temporal Focusing Line Scanning for Fast Imaging of Synaptic Structural Dynamics in vivoR21NS105070 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NEDIVI, ELLY, SO, PETER T. · 2017 to 2018
$437k
New technologies for in vivo spectral resolved high speed multiphoton microscopsyR21NS091982 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NEDIVI, ELLY, SO, PETER T. · 2015 to 2016
$429k
Development of Line-Scan Temporal Focusing for fast structural imaging of synapse assembly/disassembly in vivoF32MH115441 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOIVIN, JOSIAH R · 2017 to 2021
$231k
NCI NIH HHS U01 CA202177NHLBI NIH HHS R01 HL121386NIBIB NIH HHS P41 EB015871NIMH NIH HHS F32 MH115441NINDS NIH HHS R21 NS091982NINDS NIH HHS R21 NS105070NINDS NIH HHS U01 NS090438
6 · The paper itself

Abstract

Simultaneous, high-resolution imaging across a large number of synaptic and dendritic sites is critical for understanding how neurons receive and integrate signals. Yet, functional imaging that targets a large number of submicrometer-sized synaptic and dendritic locations poses significant technical challenges. We demonstrate a new parallelized approach to address such questions, increasing the signal-to-noise ratio by an order of magnitude compared to previous approaches. This selective access multifocal multiphoton microscopy uses a spatial light modulator to generate multifocal excitation in three dimensions (3D) and a Gaussian-Laguerre phase plate to simultaneously detect fluorescence from these spots throughout the volume. We test the performance of this system by simultaneously recording Ca

Identifiers

PMID31984218
PMCPMC6980307

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.