ArticleJournal of Indian Society of Periodontology
Clinical and radiographic evaluation of platelet-rich fibrin as an adjunct to bone grafting demineralized freeze-dried bone allograft in intrabony defects.
Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Autogenous platelet concentrates for treatment of intrabony defects-A systematic review with meta-analysis.Periodontology 2000 · 2025Pooled it
- Periodontal regeneration using platelet-rich fibrin. Furcation defects: A systematic review with meta-analysis.Periodontology 2000 · 2025Pooled it
- Review
- Polymerized injectable platelet-rich fibrin with octacalcium phosphate (bontree®) for treatment of periodontal intrabony defects assessed using CBCT: A randomized controlled clinical trial.Bioinformation · 2026Article
- Evidence for platelet-rich fibrin in combination with other regenerative materials for treatment of periodontal furcation defects: a systematic review and meta-analysis.American journal of translational research · 2026Article
- Comparative evaluation of open flap debridement with or without injectable platelet-rich fibrin in chronic periodontitis treatment.Bioinformation · 2026Article
- Guided Tissue Regeneration of Periodontal Infrabony Defects with Frozen Radiation-Sterilized Allogenic Bone Graft Versus Deproteinized Bovine Bone Mineral: 5-Year Outcomes of RCT.Journal of functional biomaterials · 2025Article
- Article
- Efficacy of Guided Tissue Regeneration Using Frozen Radiation-Sterilized Allogenic Bone Graft as Bone Replacement Graft Compared with Deproteinized Bovine Bone Mineral in the Treatment of Periodontal Intra-Bony Defects: Randomized Controlled Trial.Journal of clinical medicine · 2023Article
- Clinical Efficacy of Platelet Derivatives in Periodontal Tissue Regeneration: An Umbrella Review.International journal of dentistry · 2023Review
- Role of Biomaterials Used for Periodontal Tissue Regeneration-A Concise Evidence-Based Review.Polymers · 2022Review
- A randomized comparative study of platelet-rich fibrin along with hydroxyapatite graft for the treatment of 3-walled defects in chronic periodontitis.Medicine and pharmacy reports · 2021Article
- Comparative evaluation of regenerative potential of injectable platelet-rich fibrin and platelet-rich fibrin with demineralized freeze-dried bone allograft in the treatment of intrabony defects: A randomized controlled clinical study.National journal of maxillofacial surgeryArticle
- Comparison between the regenerative potential of different types of platelet concentrates in periodontal intrabony defect management: A systematic review.Journal of Indian Society of PeriodontologyReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral bone graft materials are popularized in the treatment of intrabony defects. Demineralized freeze-dried bone allograft (DFDBA) is widely used in the treatment of intrabony defects. Platelet-rich fibrin (PRF) is autologous blood preparation which helps in wound healing and regeneration. Hence, this study focuses on evaluation of PRF, DFDBA, and their combination in the regeneration of intrabony defects. MATERIALS AND
methodsA total of 39 sites with intrabony defects were randomly assigned into three groups: (Group I - Open flap debridement, Group II - DFDBA alone, and Group III- DFDBA + PRF). Parameters such as probing pocket depth (PPD), relative attachment level (RAL), and radiographic bone fill were measured at baseline, 3 months, and 6 months. Intragroup comparison at various study intervals was made using one-way ANOVA test. Intergroup comparison was made using Tukey's multiple
resultsReduction in the PPD and greater difference in RAL was observed over the study period in all the three groups with greater reduction in DFDBA + PRF group. Reduction in the radiographic defect depths was observed over the study period in all the three groups with the greatest reduction of 38.99% in the DFDBA + PRF group. However, no statistically significant difference was reported by DFDBA versus DFDBA + PRF group.
conclusionCombination of DFDBA and PRF improved the clinical and radiographic parameters compared to PRF and DFDBA alone. PRF was combined with DFDBA to produce a synergistic effect for treating intrabony defects in chronic periodontitis patients.
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Registered trials
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