ArticleCellulose (London, England)2018
Modulating cell response on cellulose surfaces; tunable attachment and scaffold mechanics.
Article in Cellulose (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Engineering a biomimetic multiphasic suture anchor system for enhanced rotator cuff enthesis regeneration.Science advances · 2026Article
- Development of a Scaffold from the Cob ofJournal of functional biomaterials · 2026Article
- Establishment of spontaneously immortalized Japanese eel muscle-derived preadipocyte cell lines for cultured seafood production.NPJ science of food · 2025Article
- TGF-β1/BSA coating modulates multi-phasic scaffolds for osteochondral tissue regeneration.Materials today. Bio · 2025Article
- An In Situ Characterisation Method for 3-D Electrospun Foams.Nanomaterials (Basel, Switzerland) · 2025Article
- Molecular dynamics simulation in tissue engineering.BioImpacts : BI · 2025Review
- Decellularized Macroalgae as Complex Hydrophilic Structures for Skin Tissue Engineering and Drug Delivery.Gels (Basel, Switzerland) · 2024Article
- Harnessing Natural Polymers for Nano-Scaffolds in Bone Tissue Engineering: A Comprehensive Overview of Bone Disease Treatment.Current issues in molecular biology · 2024Review
- Cellulose-Based Composites as Scaffolds for Tissue Engineering: Recent Advances.Molecules (Basel, Switzerland) · 2022Review
- Surface Modification of Bacterial Cellulose for Biomedical Applications.International journal of molecular sciences · 2022Review
- Multifunctional Finishing of Cotton with Compounds Derived from MCT-β-CD and Quantification of Effects Using MLR Statistical Analysis.Polymers · 2021Article
- Porous Optically Transparent Cellulose Acetate Scaffolds for Biomimetic Blood-Brain BarrierFrontiers in bioengineering and biotechnology · 2021Article
- Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications.Nanomaterials (Basel, Switzerland) · 2020Review
- Regenerative Capacity of Dental Pulp Stem Cells: A Systematic Review.Journal of pharmacy & bioallied sciences · 2020Review
- Surface-Modified Nanocellulose for Application in Biomedical Engineering and Nanomedicine: A Review.International journal of nanomedicine · 2020Review
- Quantified forces between HepG2 hepatocarcinoma and WA07 pluripotent stem cells with natural biomaterials correlate with in vitro cell behavior.Scientific reports · 2019Article
- Cellulose Biomaterials for Tissue Engineering.Frontiers in bioengineering and biotechnology · 2019Review
- Recent Advances in Modified Cellulose for Tissue Culture Applications.Molecules (Basel, Switzerland) · 2018Review
- Predicting Ligand-Free Cell Attachment on Next-Generation Cellulose-Chitosan Hydrogels.ACS omega · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Combining surface chemical modification of cellulose to introduce positively charged trimethylammonium groups by reaction with glycidyltrimethylammonium chloride (GTMAC) allowed for direct attachment of mammalian MG-63 cells, without addition of protein modifiers, or ligands. Very small increases in the surface charge resulted in significant increases in cell attachment: at a degree of substitution (DS) of only 1.4%, MG-63 cell attachment was > 90% compared to tissue culture plastic, whereas minimal attachment occurred on unmodified cellulose. Cell attachment plateaued above DS of ca. 1.85% reflecting a similar trend in surface charge, as determined from ζ-potential measurements and capacitance coupling (electric force microscopy). Cellulose film stiffness was modulated by cross linking with glyoxal (0.3-2.6% degree of crosslinking) to produce a range of materials with surface shear moduli from 76 to 448 kPa (measured using atomic force microscopy). Cell morphology on these materials could be regulated by tuning the stiffness of the scaffolds. Thus, we report tailored functionalised biomaterials based on cationic cellulose that can be tuned through surface reaction and glyoxal crosslinkin+g, to influence the attachment and morphology of cells. These scaffolds are the first steps towards materials designed to support cells and to regulate cell morphology on implanted biomaterials using only scaffold and cells, i.e. without added adhesion promoters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.