ArticleThe journal of sexual medicine2020
Intraoperative Intracavernosal Liposomal Bupivacaine (Exparel) Injection Does Not Affect Systemic Hemodynamics.
Article in The journal of sexual medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Liposomal bupivacaine versus conventional anesthetics in adductor canal block for total knee arthroplasty: a meta-analysis of randomized controlled trials.BMC anesthesiology · 2025Pooled it
- Evolving Trends and Core Contributors: A Bibliometric Update on Liposomal Bupivacaine.Pain research & management · 2026Article
- Recent advances in pain management based on nanoparticle technologies.Journal of nanobiotechnology · 2022Review
- Re: Intraoperative intracavernosal liposomal bupivacaine (Exparel) injection does not affect systemic hemodynamics.International journal of impotence research · 2021Article
- Levobupivacaine-Loaded Liposome Associated with Thermogel for Prolonged Analgesia.AAPS PharmSciTech · 2021Article
- Long-acting liposomal bupivacaine and postoperative opioid use after Peyronie's disease surgery: a pilot study.Translational andrology and urology · 2021Article
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2 authors at 1 institution in 2 countries.
Funding
Abstract
introductionThe systemic effect of intracavernosal liposomal bupivacaine (Exparel) injection during inflatable penile prosthesis (IPP) implantation on systemic hemodynamics has not been clarified.
aimTo evaluate whether intraoperative intracavernosal Exparel injection affects systemic hemodynamics.
methodsWe studied 56 consecutive patients who underwent IPP implantation under general anesthesia using the transverse scrotal approach. Exparel [10 mL of 1.3% (13.3 mg/mL)] was instilled bilaterally intracavernosally via a 25-gauge needle around 30 min after starting the surgery. All patients graded their postoperative pain using a standard 10-point scale.
main outcome measurePerioperative vital signs at defined time intervals and postoperative pain were monitored. The degree of postoperative pain were analyzed using a standard 10-point scale.
resultsMedians and interquartile ranges (IQRs) of the patients' age [64 years (57.3-69.3)], operation time [85 min (78-96)], and estimated blood loss [75 mL (29-100)] were recorded. Although the median preoperative systolic noninvasively measured blood pressure of 131 mm/Hg (IQR: 122-139) fell by 25% to 98 mm/Hg (IQR: 90-100) (P < .001) after anesthesia started, there was no significant decrease in blood pressure between before and after Exparel injection. The perioperative pulse rate and pulse oximetry oxygen saturation were stable. Neither arrhythmia nor convulsion occurred. Patients reported postoperative pain as 0 (IQR: 0-2.25) on a scale of 0-10. CLINICAL IMPLICATIONS: Intraoperative intracavernosal Exparel injection is safe and effective in patients undergoing IPP implantation surgery. STRENGTH & LIMITATIONS: This is the first report to describe systemic hemodynamics of intracavernosal Exparel injection. Limitations are lack of blood concentration of Exparel at various time points and long-term follow-up for pain assessment.
conclusionAlthough limited by a lack of the blood concentration of Exparel and short follow-up for pain assessment, we concluded that intraoperative intracavernosal Exparel injection does not affect systemic hemodynamics. Taniguchi H, Mulhall JP. Intraoperative Intracavernosal Liposomal Bupivacaine (Exparel) Injection Does Not Affect Systemic Hemodynamics. J Sex Med 2020;17:526-530.
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