ArticleAmerican journal of surgery2020
The impact of cirrhosis and MELD score on postoperative morbidity and mortality among patients selected for liver resection.
Article in American journal of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Prognostic role of preoperative albumin-bilirubin score in posthepatectomy liver failure and mortality: a systematic review and meta-analysis.Updates in surgery · 2022Pooled it
- Outcomes of Clostridium difficile infection in liver transplant patients: A systematic review and meta-analysis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Review
- The association between cirrhosis and outcomes among patients with lung cancer in Ontario between 2007 and 2017: A population-based study.Canadian liver journal · 2026Article
- Noninvasive Tests for Liver Fibrosis Predict Postoperative Complications After Resection of Colorectal Liver Metastases.Annals of surgical oncology · 2026Article
- Soluble TREM2 reflects liver fibrosis status and predicts postoperative liver dysfunction after liver surgery.JHEP reports : innovation in hepatology · 2025Article
- Outcomes of liver resection in hepatitis C virus-related intrahepatic cholangiocarcinoma: A systematic review and meta-analysis.World journal of virology · 2024Article
- Developing and validating a nomogram based on skeletal muscle index and clinical scoring system for prediction of liver failure after hepatectomy.Frontiers in oncology · 2023Article
- Performance of risk prediction models for post-operative mortality in patients undergoing liver resection.American journal of surgery · 2023Article
- Predictors of Liver Failure in Non-Cirrhotic Patients Undergoing Hepatectomy.World journal of surgery · 2022Article
- Article
- A novel preoperative predictive model of 90-day mortality after liver resection for huge hepatocellular carcinoma.Annals of translational medicine · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIndependent associations between chronic liver disease, MELD, and postoperative outcomes among patients selected for liver resection have not been completely established. We hypothesized independent associations between MELD, cirrhosis, and postoperative mortality.
methodsPatient-level data from the targeted hepatectomy module and ACS NSQIP PUF during 2014-2015 were merged. Multivariable regression models with interaction effect between MELD and liver texture (normal, congested/fatty, cirrhotic) tested the independent effects of covariates on mortality and morbidity.
results3,530 patients were included, of whom 668 patients (19%) had cirrhosis. ACS NSQIP defined mortality (3.9%vs1.1%) and morbidity (23.5%vs15.8%) were higher in patients with cirrhosis (both p < 0.001). In multivariable models, cirrhosis (OR = 2.24; 95%CI:1.16-4.34, p = 0.016) and MELD (OR = 1.10; 95%CI:1.03-1.18, p = 0.007) were independently associated with mortality. MELD (OR = 1.04; 95%CI:1.002-1.08, p = 0.038) was associated with postoperative morbidity.
conclusionsHigher MELD and presence of cirrhosis have an independent negative effect on mortality after liver resection. MELD could be used to estimate postoperative risk in patients with and without cirrhosis.
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