ArticleJournal of the American Heart Association2020
Genetic Risk of Coronary Artery Disease, Features of Atherosclerosis, and Coronary Plaque Burden.
Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Baseline Computed Tomography Coronary Angiography and Polygenic Risk Profiles in Adults With Type 2 Diabetes: A Cross-Sectional Analysis From the VOLTAIRE Study.Diabetes, obesity & metabolism · 2026Trial
- Use of a polygenic risk score to enhance early detection of coronary atherosclerosis.American journal of preventive cardiology · 2026Article
- Improving Polygenic Risk Prediction for Atherosclerotic Cardiovascular Disease in East Asian Populations.JACC. Asia · 2026Review
- Screening for high coronary plaque volume in primary prevention: integration of multi-omics and coronary calcium scoring into cardiovascular risk assessment.American journal of preventive cardiology · 2026Article
- Pharmacogenomics of Atherosclerotic Plaque: Pathophysiological Background and Therapeutic Perspectives.Current atherosclerosis reports · 2026Review
- Polygenic risk score predicts presence of subclinical atherosclerosis in first-degree relatives of patients with premature coronary artery disease.American journal of preventive cardiology · 2026Article
- Appraisal of multiple polygenic risk scores to estimate the risk of myocardial infarction and coronary artery lesions.Communications medicine · 2025Article
- Tianxiangdan suppresses foam cell formation by enhancing lipophagy and reduces the progression of atherosclerosis.In vitro cellular & developmental biology. Animal · 2025Article
- Genomic Drivers of Coronary Artery Disease and Risk of Future Outcomes After Coronary Angiography.JAMA network open · 2025Article
- Polygenic Risk Is Associated With Long-Term Coronary Plaque Progression and High-Risk Plaque.JACC. Cardiovascular imaging · 2024Article
- Polygenic Risk Scores and Extreme Coronary Artery Calcium Phenotypes (CAC=0 and CAC≥1000) in Adults ≥75 Years Old: The ARIC Study.Circulation. Cardiovascular imaging · 2024Article
- Polygenic Risk and Coronary Artery Disease Severity.Circulation. Genomic and precision medicine · 2024Article
- Use of Machine Learning for the Identification and Validation of Immunogenic Cell Death Biomarkers and Immunophenotypes in Coronary Artery Disease.Journal of inflammation research · 2024Article
- Clinical applications of polygenic risk score for coronary artery disease through the life course.Atherosclerosis · 2023Review
- Danish study of Non-Invasive Testing in Coronary Artery Disease 3 (Dan-NICAD 3): study design of a controlled study on optimal diagnostic strategy.Open heart · 2023Article
- DanMAC5: a browser of aggregated sequence variants from 8,671 whole genome sequenced Danish individuals.BMC genomic data · 2023Article
- Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial.American heart journal · 2022Article
- Expression ratio of circular to linear ANRIL in hypertensive patients with coronary artery disease.Scientific reports · 2022Article
- The Role of ANRIL in Atherosclerosis.Disease markers · 2022Review
- Present and future of coronary risk assessment.European heart journal supplements : journal of the European Society of Cardiology · 2021Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Polygenic risk scores (PRSs) based on risk variants from genome-wide association studies predict coronary artery disease (CAD) risk. However, it is unknown whether the PRS is associated with specific CAD characteristics. Methods and Results We consecutively included 1645 patients with suspected stable CAD undergoing coronary computed tomography angiography. A multilocus PRS was calculated as the weighted sum of CAD risk variants. Plaques were evaluated using an 18-segment model and characterized by stenosis severity and composition (soft [0%-19% calcified], mixed-soft [20%-49% calcified], mixed-calcified [50%-79% calcified], or calcified [≥80% calcified]). Coronary artery calcium score and segment stenosis score were used to characterize plaque burden. For each standard deviation increase in the PRS, coronary artery calcium score increased by 78% (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.