Evidence map›Paper›PMID 31983310›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

Somatic

Kazutaka Nanba, Amy R Blinder, Juilee Rege, Namita G Hattangady, Tobias Else, Chia-Jen Liu, Scott A Tomlins, Pankaj Vats, Chandan Kumar-Sinha, Thomas J Giordano and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 102 citations in OpenAlex.

  1. Primary aldosteronism.Nature reviews. Disease primers · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. The genetics of hypertension.Nature reviews. Nephrology · 2026
    Review
  9. Adrenal causes of endocrine hypertension in childhood or adolescence.Journal of endocrinological investigation · 2025
    Review
  10. Somatic Mutations inHypertension (Dallas, Tex. : 1979) · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. SomaticHypertension (Dallas, Tex. : 1979) · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. A Review of theDiseases (Basel, Switzerland) · 2024
    Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Kazutaka NanbaFrom the Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor (K.N., A.R.B., J.R., W.E.R.).
Amy R BlinderFrom the Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor (K.N., A.R.B., J.R., W.E.R.).
Juilee RegeFrom the Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor (K.N., A.R.B., J.R., W.E.R.).
Namita G HattangadyDivision of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor (N.G.H., T.E., T.J.G., W.E.R.).
Tobias ElseDivision of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor (N.G.H., T.E., T.J.G., W.E.R.).
Chia-Jen LiuDepartment of Pathology, University of Michigan, Ann Arbor (C.-J.L., S.A.T., P.V., C.K.-S., T.J.G.).
Scott A TomlinsDepartment of Pathology, University of Michigan, Ann Arbor (C.-J.L., S.A.T., P.V., C.K.-S., T.J.G.).
Pankaj VatsDepartment of Pathology, University of Michigan, Ann Arbor (C.-J.L., S.A.T., P.V., C.K.-S., T.J.G.).
Chandan Kumar-SinhaDepartment of Pathology, University of Michigan, Ann Arbor (C.-J.L., S.A.T., P.V., C.K.-S., T.J.G.).
Thomas J GiordanoDepartment of Pathology, University of Michigan, Ann Arbor (C.-J.L., S.A.T., P.V., C.K.-S., T.J.G.).
William E RaineyFrom the Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor (K.N., A.R.B., J.R., W.E.R.).
University of Michigan–Ann Arbor · USU-M Rogel Cancer Center

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
Adrenal Origins of Aldosterone ExcessR01DK106618 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI William E Rainey, Aaron Mark Udager · 2016 to 2026
$6.0M
The Genetics of Primary AldosteronismR01HL130106 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELSE, TOBIAS · 2016 to 2020
$1.9M
NCI NIH HHS P30 CA046592NHLBI NIH HHS R01 HL130106NIDDK NIH HHS R01 DK106618
6 · The paper itself

Abstract

Driver somatic mutations for aldosterone excess have been found in ≈90% of aldosterone-producing adenomas (APAs) using an aldosterone synthase (CYP11B2)-guided sequencing approach. In the present study, we identified a novel somatic

Indexed as

AdenomaAdrenal Cortex NeoplasmsAldosteroneAngiotensin IICalcium Channels, T-TypeCalcium SignalingCell Line, TumorCytochrome P-450 CYP11B2DoxycyclineEnzyme InductionExome SequencingGenetic VectorsHigh-Throughput Nucleotide SequencingHumansHyperaldosteronismLentivirusAldosteroneAngiotensin IICACNA1H protein, humanCalcium Channels, T-TypeCytochrome P-450 CYP11B2DoxycyclineRecombinant ProteinsRNA, MessengerRNA, NeoplasmAldosteroneAldosterone-producing adenomaCalcium channelCYP11B2MutationPrimary aldosteronism

Identifiers

PMID31983310
PMCPMC7059016
OpenAlexW3003524758

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.