Evidence map›Paper›PMID 31983265›Full record

ArticleRNA biology2020

tRNA-derived fragments and microRNAs in the maternal-fetal interface of a mouse maternal-immune-activation autism model.

Zhangli Su, Elizabeth L Frost, Catherine R Lammert, Roza K Przanowska, John R Lukens, Anindya Dutta

Open access · bronzeAbstract read
In one paragraph

Article in RNA biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 47 citations in OpenAlex.

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  10. The serum small non-coding RNA (SncRNA) landscape as a molecular biomarker of age associated muscle dysregulation and insulin resistance in older adults.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zhangli SuDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia , Charlottesville, VA, USA.
Elizabeth L FrostCenter for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia , Charlottesville, VA, USA.
Catherine R LammertCenter for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia , Charlottesville, VA, USA.ORCID 0000-0002-9822-7128
Roza K PrzanowskaDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia , Charlottesville, VA, USA.ORCID 0000-0003-1278-6242
John R LukensCenter for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia , Charlottesville, VA, USA.ORCID 0000-0002-6795-0866
Anindya DuttaDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia , Charlottesville, VA, USA.
University of Virginia · US

Funding

Mechanism of action of an lncRNA for directing muscle differentiationR01AR067712 · NIAMS · UNIVERSITY OF VIRGINIA · PI DUTTA, ANINDYA · 2016 to 2020
$1.7M
American Heart Association-American Stroke Association 18PRE33990261NIAMS NIH HHS R01 AR067712
6 · The paper itself

Abstract

tRNA-derived small fragments (tRFs) and tRNA halves have emerging functions in different biological pathways, such as regulating gene expression, protein translation, retrotransposon activity, transgenerational epigenetic changes and response to environmental stress. However, small RNAs like tRFs and microRNAs in the maternal-fetal interface during gestation have not been studied extensively. Here we investigated the small RNA composition of mouse placenta/decidua, which represents the interface where the mother communicates with the foetus, to determine whether there are specific differences in tRFs and microRNAs during fetal development and in response to maternal immune activation (MIA). Global tRF expression pattern, just like microRNAs, can distinguish tissue types among placenta/decidua, fetal brain and fetal liver. In particular, 5' tRNA halves from tRNA

Indexed as

AnimalsAutistic DisorderDeciduaFemaleGene Expression RegulationMiceMicroRNAsPlacentaPregnancyRNA, Small UntranslatedRNA, TransferMicroRNAsRNA, Small UntranslatedRNA, Transferautismmaternal fetal interfacematernal immune activationmicroRNAnon-coding RNAplacentaRNA metabolismsmall RNATransfer RNAtRNA fragment

Identifiers

PMID31983265
PMCPMC7549640
OpenAlexW3003453550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.