ArticleAsian Pacific journal of cancer prevention : APJCP2020
Cytotoxicity and Synergistic Effect of Biogenically Synthesized Ternary Therapeutic Nano Conjugates Comprising Plant Active Principle, Silver and Anticancer Drug on MDA-MB-453 Breast Cancer Cell Line.
Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Evaluation of hepatic cancer stem cells (CDMolecular biology reports · 2025Article
- Formulation of quinoa oil-alginate loaded nanoemulsion and its anticancer efficacy as a therapy for chemically induced breast cancer.Molecular biology reports · 2024Article
- Fungal-Mediated Silver Nanoparticle and Biochar Synergy against Colorectal Cancer Cells and Pathogenic Bacteria.Antibiotics (Basel, Switzerland) · 2023Article
- Andrographolide stabilized-silver nanoparticles overcome ceftazidime-resistant Burkholderia pseudomallei: study of antimicrobial activity and mode of action.Scientific reports · 2022Article
- Targeting Engineered Nanoparticles for Breast Cancer Therapy.Pharmaceutics · 2021Review
- Exploring combined herbal extract-loaded phytoniosomes for antimalarial and antibacterial activity against methicillin-resistant3 Biotech · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
Drug delivery through biogenically synthesized silver nanoparticles (AgNPs) in cancer treatment is exerted by smaller size entailing high surface area and synergistic effects of embedded biomolecules. In this study, prepared ternary conjugates of silver with plant active compound and anticancer drug towards reducing the dose through synergy, rendered by Electrostatic Attraction (EA) of functionalized drug on to the surface of biogenically synthesized AgNPs. The biogenic synthesis resulted in particles of nanometer range as well as serving reducing and capping agents. The cytotoxicity and synergistic effect of ternary therapeutic nano conjugates evaluated using MDA-MB-453 breast cancer cells were found to be superior than Doxorubicin (Dox). Quantitative HPTLC analysis showed 57.22 % inhibition by Dox-AP-AgNPs at a concentration of 2.5 µg/mL of Andrographolide and 0.95 µg/mL of Dox validating synergistic effect of the ternary conjugate.
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