ArticleAsian Pacific journal of cancer prevention : APJCP2020
Comparative Study on the Anticancer Drug Potential of a Lectin Purified from Aloe Vera and Aloe-Emodin.
Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Mechanism of action ofOncology letters · 2025Article
- Exploring the anticancer potential of traditional herbs from Tamil Nadu: a narrative review of ethnomedicinal insights and scientific evidence.Frontiers in immunology · 2025Review
- Review
- Aloe-emodin: Progress in Pharmacological Activity, Safety, and Pharmaceutical Formulation Applications.Mini reviews in medicinal chemistry · 2024Review
- Effects of Carbon Nanomaterials andPharmaceutics · 2022Review
- Microbial Biosynthesis of Chrysazin Derivatives in RecombinantMolecules (Basel, Switzerland) · 2022Article
- Emodin enhances cisplatin sensitivity in non-small cell lung cancer through Pgp downregulation.Oncology letters · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of Aloctin, a lectin purified from Aloe vera leaves, and aloe emodin an anthraquinone glycoside purified from the leaves of the same plant, on several cancer cell lines was investigated.
methodsAloctin was isolated from A. vera leaf skin by ammonium sulphate precipitation and CNBr-Sepharose 4B-ovalbumin affinity chromatography. Specific new ligands for Aloctin were detected as fetuin and avidin by hemagglutination inhibition tests. The cytotoxic effect of Aloctin and aloe emodin on various human cancer cell lines was tested using MTT assay. Imatinib was tested as standard positive control. The mechanism underlying was tested by the Annexin V-FITC/PI test, with flow cytometry.
resultsThe most sensitive cells to Aloctin and aloe emodin treatment, were identified as AGS human gastric adenocarcinoma cells. The effect was concentration dependent. It was shown that this effect does not occur by apoptosis or necrosis. In Aloctin-imatinib combinations studies, Aloctin significantly increased the cytotoxic effect of imatinib in a dose-dependent manner. It is expected that the results of this study will reveal important findings for the future use of A. vera lectin as well as aloe emodin in cancer research and contribution to lectin biochemistry.<br />.
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